A concise colorimetric and fluorimetric probe for sarin related threats designed via the "covalent-assembly" approach.

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Abstract

A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The "covalent-assembly" probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous Vilsmeier-Haack reaction. NA570 bears a concise molecular construct, exhibits a colorimetric and a fluorimetric signal, and has potential for real applications.

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Journal

Journal ID (iso-abbrev): J. Am. Chem. Soc.

Title: Journal of the American Chemical Society

Publisher: American Chemical Society (ACS)

ISSN (Electronic): 1520-5126

ISSN (Print): 0002-7863

Publication date (Electronic): May 07 2014

Volume: 136

Issue: 18

Affiliations

[1 ] State Key Laboratory of Bioreactor Engineering, ‡Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.

Article

DOI: 10.1021/ja502945q

PubMed ID: 24766398

SO-VID: b0ee447f-473f-49c3-ac84-c58be90bad17

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