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Abstract
<p id="d7422784e189">It has long been debated whether the mechanisms that underlie
language are dedicated
to this uniquely human capacity or whether in fact they serve more general-purpose
functions. Our study provides strong evidence that language—indeed both first and
second language—is learned, in specific ways, by general-purpose neurocognitive mechanisms
that preexist
<i>Homo sapiens</i>. The results have broad implications. They elucidate both the
ontogeny (development)
and phylogeny (evolution) of language. Moreover, they suggest that our substantial
knowledge of the general-purpose mechanisms, from both animal and human studies, may
also apply to language. The study may thus lead to a research program that can generate
a wide range of predictions about this critical domain.
</p><p class="first" id="d7422784e195">Do the mechanisms underlying language in fact
serve general-purpose functions that
preexist this uniquely human capacity? To address this contentious and empirically
challenging issue, we systematically tested the predictions of a well-studied neurocognitive
theory of language motivated by evolutionary principles. Multiple metaanalyses were
performed to examine predicted links between language and two general-purpose learning
systems, declarative and procedural memory. The results tied lexical abilities to
learning only in declarative memory, while grammar was linked to learning in both
systems in both child first language and adult second language, in specific ways.
In second language learners, grammar was associated with only declarative memory at
lower language experience, but with only procedural memory at higher experience. The
findings yielded large effect sizes and held consistently across languages, language
families, linguistic structures, and tasks, underscoring their reliability and validity.
The results, which met the predicted pattern, provide comprehensive evidence that
language is tied to general-purpose systems both in children acquiring their native
language and adults learning an additional language. Crucially, if language learning
relies on these systems, then our extensive knowledge of the systems from animal and
human studies may also apply to this domain, leading to predictions that might be
unwarranted in the more circumscribed study of language. Thus, by demonstrating a
role for these systems in language, the findings simultaneously lay a foundation for
potentially important advances in the study of this critical domain.
</p>
Our capacity to store information in working memory might be determined by the degree to which only relevant information is remembered. The question remains as to how this selection of relevant items to be remembered is accomplished. Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, predicted the extent to which only relevant information is stored. The preceding frontal and basal ganglia activity were also associated with inter-individual differences in working memory capacity. These findings reveal a mechanism by which frontal and basal ganglia activity exerts attentional control over access to working memory storage in the parietal cortex in humans, and makes an important contribution to inter-individual differences in working memory capacity.
Work with patient H.M., beginning in the 1950s, established key principles about the organization of memory that inspired decades of experimental work. Since H.M., the study of human memory and its disorders has continued to yield new insights and to improve understanding of the structure and organization of memory. Here we review this work with emphasis on the neuroanatomy of medial temporal lobe and diencephalic structures important for memory, multiple memory systems, visual perception, immediate memory, memory consolidation, the locus of long-term memory storage, the concepts of recollection and familiarity, and the question of how different medial temporal lobe structures may contribute differently to memory functions.
Neuroscientists have debated for centuries whether some regions of the human brain are selectively engaged in specific high-level mental functions or whether, instead, cognition is implemented in multifunctional brain regions. For the critical case of language, conflicting answers arise from the neuropsychological literature, which features striking dissociations between deficits in linguistic and nonlinguistic abilities, vs. the neuroimaging literature, which has argued for overlap between activations for linguistic and nonlinguistic processes, including arithmetic, domain general abilities like cognitive control, and music. Here, we use functional MRI to define classic language regions functionally in each subject individually and then examine the response of these regions to the nonlinguistic functions most commonly argued to engage these regions: arithmetic, working memory, cognitive control, and music. We find little or no response in language regions to these nonlinguistic functions. These data support a clear distinction between language and other cognitive processes, resolving the prior conflict between the neuropsychological and neuroimaging literatures.
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