Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNFα therapy.

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Abstract

Anti-tumour necrosis factor α (TNFα) therapy effectively induces and maintains remission in Crohn's disease (CD). Up to 40% of patients, however, fail to respond to anti-TNFα.

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Journal ID (iso-abbrev): Gut

Title: Gut

Publisher: BMJ

ISSN (Electronic): 1468-3288

ISSN (Print): 0017-5749

Publication date (Electronic): Feb 2015

Volume: 64

Issue: 2

Affiliations

[1 ] Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain Postdoctoral CAPES fellow, Brazil.

[2 ] Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain Bioinformatics Platform, CIBERehd, Barcelona, Spain.

[3 ] Hoffmann-La Roche, Nutley, New Jersey, USA Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.

[4 ] Bioinformatics Platform, CIBERehd, Barcelona, Spain.

[5 ] Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.

[6 ] Hoffmann-La Roche, Nutley, New Jersey, USA EMD Serono Research & Development Institute, Boston, Massachusetts, USA.

Article

Publisher Item ID: gutjnl-2013-306518

DOI: 10.1136/gutjnl-2013-306518

PubMed ID: 24700437

SO-VID: b0b8267c-eee2-42cb-8569-ed523e704ed3

History

Keywords: CROHN'S DISEASE,IBD BASIC RESEARCH,INFLAMMATORY MEDIATORS,TNF-ALPHA

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Keywords: CROHN'S DISEASE, IBD BASIC RESEARCH, INFLAMMATORY MEDIATORS, TNF-ALPHA

Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNFα therapy.

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