Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

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Abstract

User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently needed at points of care in resource-limited settings. We investigated host biomarkers detected in serum samples obtained from adults with signs and symptoms suggestive of TB at primary healthcare clinics in five African countries (Malawi, Namibia, South Africa, The Gambia and Uganda), for the diagnosis of TB disease.

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Journal

Journal ID (iso-abbrev): Thorax

Title: Thorax

Publisher: BMJ

ISSN (Electronic): 1468-3296

ISSN (Print): 0040-6376

Publication date (Electronic): Sep 2016

Volume: 71

Issue: 9

Affiliations

[1 ] Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

[2 ] Vaccines and Immunity, Medical Research Council Unit, Fajara, The Gambia.

[3 ] Karonga Prevention Study, Chilumba, Malawi.

[4 ] Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands.

[5 ] Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands.

[6 ] Department of Medicine, Makerere University, Kampala, Uganda.

[7 ] Faculty of Health Sciences, School of Medicine, University of Namibia, Windhoek, Namibia.

[8 ] Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.

[9 ] Department of Statistics and Actuarial Sciences, Centre for Statistical Consultation, Stellenbosch University, Cape Town, South Africa.

[10 ] Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK.

[11 ] Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

Article

Publisher Item ID: thoraxjnl-2015-207999

DOI: 10.1136/thoraxjnl-2015-207999

PubMed ID: 27146200

SO-VID: b091bd9c-be5e-49d0-8e33-1fffa312703d

History

Keywords: Tuberculosis

Data availability:

Keywords: Tuberculosis

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