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      Andexanet alfa — Recommendations for clinical use. Multidisciplinary experts’ standpoint

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          Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

          Andexanet alfa is a modified recombinant inactive form of human factor Xa developed for reversal of factor Xa inhibitors.
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            Idarucizumab for Dabigatran Reversal - Full Cohort Analysis.

            Idarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran.
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              Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity.

              Bleeding is a complication of treatment with factor Xa inhibitors, but there are no specific agents for the reversal of the effects of these drugs. Andexanet is designed to reverse the anticoagulant effects of factor Xa inhibitors.
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                Author and article information

                Journal
                Cardiol J
                Cardiol J
                Cardiology Journal
                Via Medica
                1897-5593
                1898-018X
                2023
                31 August 2023
                : 30
                : 4
                : 502-505
                Affiliations
                [1 ]Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
                [2 ]Gajda-Med Medical Center, Pultusk, Poland
                [3 ]3 rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
                [4 ]Department of Cardiology, Institute of Medical Sciences, University of Opole, Poland
                [5 ]Mossakowski Medical Research Institute, Polish Academy of Science, Warsaw, Poland
                [6 ]1 st Department of Cardiology, Medical University of Gdansk, Poland
                [7 ]Department of Cardiac Rehabilitation and Health Promotion, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
                [8 ]Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland
                [9 ]Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, Poland
                [10 ]Department of Emergency Medicine, Medical University of Bialystok, Poland
                [11 ]Department of Cardiology, Medical University of Bialystok, Poland
                Author notes
                Address for correspondence: Prof. Jacek Kubica, Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, ul. M. Skłodowskiej-Curie 9, 85–094 Bydgoszcz, Poland, e-mail: jkubica@ 123456cm.umk.pl
                Author information
                https://orcid.org/0000-0001-8250-754X
                https://orcid.org/0000-0001-9719-0987
                https://orcid.org/0000-0002-4608-0881
                Article
                cardj-30-4-502
                10.5603/CJ.a2023.0043
                10508081
                37401419
                b0428ea2-8314-4b24-aefd-fbe379bf00fc
                Copyright © 2023 Via Medica

                This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially

                History
                : 23 May 2023
                : 15 June 2023
                Categories
                Clinical Cardiology
                Experts’ Viewpoint

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