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      COVID-19 Pandemic Quarantines and Mental Health Among Adolescents in Norway

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          Abstract

          This cohort study examines the association of mental health and the public health measures and quarantine experiences during the COVID-19 pandemic among Norwegian adolescents.

          Key Points

          Question

          How were stringent public health measures and quarantine during the COVID-19 pandemic associated with mental distress among Norwegian adolescents, and did vulnerability factors moderate the associations?

          Findings

          In this cohort study of 7787 participants, stricter public health measures and quarantine were associated with adolescent mental distress. Younger adolescents, those with parents with lower education, or those with lower genetic liability to depression showed particularly elevated mental distress by more frequent quarantines.

          Meaning

          These findings suggest the need for targeted support to protect adolescent well-being during future crises and emphasize the possible ongoing risk of mental health problems in adolescents following the COVID-19 pandemic.

          Abstract

          Importance

          Adolescence is a critical developmental phase when mental health disorders, such as anxiety and depression, often emerge. Stringent public health measures and quarantine mandates during the COVID-19 pandemic could threaten adolescent mental health.

          Objective

          To investigate the associations of public health measures and quarantine experiences with mental distress among Norwegian adolescents and to explore if certain vulnerability factors moderate these associations.

          Design, Setting, and Participants

          This longitudinal cohort study used repeated measures to capture variations in mental distress explained by the stringency of public health measures and quarantine experiences. Data from the Norwegian Mother, Father, and Child cohort study were linked to national health registries and a national stringency index from April 1, 2020, to February 17, 2021. Participant included 7787 Norwegian adolescents aged 16 to 18 years. Data were analyzed from October 2022 to October 2023.

          Exposures

          Stringency index of public health measures and quarantine experiences including recent quarantine (within the last 2 weeks) and quarantine frequency (cumulative number of quarantine episodes).

          Main Outcome and Measures

          Mental distress was measured using the Hopkins Symptom Checklist across 6 data collection waves.

          Results

          In this study, 7787 participants were included in the analysis (4473 female [57%]; mean [SD] age, 17.0 [0.6] years). Stringent public health measures (β = 0.18; SE, 0.02; P < .001), recent quarantine (β = 0.11; SE, 0.02; P < .001), and frequent quarantine (β = 0.08; SE, 0.01; P < .001) were associated with higher levels of mental distress. The associations between public health measures and mental distress were not moderated by sex, age, prepandemic anxiety or depression, or genetic liability for mental health conditions. Frequency of quarantine appeared to be more strongly associated with mental distress among younger adolescents (β = −0.04; SE, 0.01; P = .008), those with parents with lower education (β = −0.04; SE, 0.01; P = .007), and those with lower genetic risk for depression (β = −0.03; SE, 0.01; P = .006).

          Conclusions and Relevance

          In this study, younger adolescents, those with parents with lower education, or those with low genetic liability for depression appeared more vulnerable when being quarantined several times. These findings emphasize the need for targeted support strategies to better protect adolescent well-being during future crises. Adolescents who experienced increased mental distress during the COVID-19 pandemic may be at risk of continued mental health problems and in need of ongoing support.

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          Most cited references50

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          The psychological impact of quarantine and how to reduce it: rapid review of the evidence

          Summary The December, 2019 coronavirus disease outbreak has seen many countries ask people who have potentially come into contact with the infection to isolate themselves at home or in a dedicated quarantine facility. Decisions on how to apply quarantine should be based on the best available evidence. We did a Review of the psychological impact of quarantine using three electronic databases. Of 3166 papers found, 24 are included in this Review. Most reviewed studies reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger. Stressors included longer quarantine duration, infection fears, frustration, boredom, inadequate supplies, inadequate information, financial loss, and stigma. Some researchers have suggested long-lasting effects. In situations where quarantine is deemed necessary, officials should quarantine individuals for no longer than required, provide clear rationale for quarantine and information about protocols, and ensure sufficient supplies are provided. Appeals to altruism by reminding the public about the benefits of quarantine to wider society can be favourable.
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            The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

            Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative developed recommendations on what should be included in an accurate and complete report of an observational study. We defined the scope of the recommendations to cover three main study designs: cohort, case-control, and cross-sectional studies. We convened a 2-day workshop in September, 2004, with methodologists, researchers, and journal editors to draft a checklist of items. This list was subsequently revised during several meetings of the coordinating group and in e-mail discussions with the larger group of STROBE contributors, taking into account empirical evidence and methodological considerations. The workshop and the subsequent iterative process of consultation and revision resulted in a checklist of 22 items (the STROBE statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.18 items are common to all three study designs and four are specific for cohort, case-control, or cross-sectional studies.A detailed explanation and elaboration document is published separately and is freely available on the websites of PLoS Medicine, Annals of Internal Medicine, and Epidemiology. We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies
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              A general and simple method for obtainingR2from generalized linear mixed-effects models

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                Author and article information

                Journal
                JAMA Netw Open
                JAMA Netw Open
                JAMA Network Open
                American Medical Association
                2574-3805
                12 July 2024
                July 2024
                12 July 2024
                : 7
                : 7
                : e2422189
                Affiliations
                [1 ]PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway
                [2 ]Department of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway
                [3 ]Department of Psychology, University of Oslo, Oslo, Norway
                [4 ]Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway
                [5 ]Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
                [6 ]Department of Children and Families, Norwegian Institute of Public Health, Oslo, Norway
                [7 ]Department of Psychology, Manchester Metropolitan University, Bristol, Untied Kingdom
                [8 ]Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway
                [9 ]The Norwegian Mother, Father, and Child Cohort Study (MoBa), Norwegian Institute of Public Health, Oslo, Norway
                Author notes
                Article Information
                Accepted for Publication: May 15, 2024.
                Published: July 12, 2024. doi:10.1001/jamanetworkopen.2024.22189
                Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2024 Pettersen JH et al. JAMA Network Open.
                Corresponding Author: Johanne H. Pettersen, MPhil, Norwegian Institute of Public Health, Marcus Thranes Gate 6, 0473, Oslo, Norway ( johannehagen.pettersen@ 123456fhi.no ).
                Author Contributions: Ms Pettersen had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
                Concept and design: Pettersen, Hannigan, Nesvåg, Brandlistuen, Ask.
                Acquisition, analysis, or interpretation of data: Pettersen, Hannigan, Gustavson, Lund, Pearson, Jensen, Brandlistuen, Ask.
                Drafting of the manuscript: Pettersen.
                Critical review of the manuscript for important intellectual content: All authors.
                Statistical analysis: Pettersen, Hannigan, Gustavson.
                Obtained funding: Brandlistuen, Ask.
                Administrative, technical, or material support: Lund.
                Supervision: Gustavson, Nesvåg, Brandlistuen, Ask.
                Conflict of Interest Disclosures: None reported.
                Funding/Support: Ms Pettersen, Ms Jensen, and Drs Nesvåg, Brandlistuen, and Ask were supported by grant 324620 from the Research Council of Norway. Drs Lund, Brandlistuen, and Ask were supported by grants 156298 and 138929 from NordForsk. Dr Hannigan was supported by grants 2019097 and 2022083 from the Ministry of Health and Care Services. The Norwegian Mother, Father, and Child cohort study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research.
                Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
                Disclaimer: The interpretation and reporting of these data are the sole responsibility of the authors, and no endorsement by the Norwegian Patient Registry is intended nor should be inferred.
                Data Sharing Statement: See Supplement 2.
                Additional Contributions: We thank the participating families in Norway who took part in the ongoing Norwegian Mother, Father, and Child cohort study. We thank the Norwegian Institute of Public Health for generating high-quality genomic data, which is part of the HARVEST collaboration and supported by the Research Council of Norway (RCN). We also thank the NORMENT Centre for providing genotype data, which is funded by the RCN, South East Norway, Health Authorities, and Stiftelsen Kristian Gerhard Jebsen. We further thank the Center for Diabetes Research at the University of Bergen for providing genotype data and performing quality control and imputation of the data, which is funded by the ERC AdG project SELECTionPREDISPOSED, Stiftelsen Kristian Gerhard Jebsen, Trond Mohn Foundation, the RCN, the Novo Nordisk Foundation, the University of Bergen, and the Western Norway Health Authorities.
                Article
                zoi240708
                10.1001/jamanetworkopen.2024.22189
                11245726
                38995642
                b02a24dd-8ad6-4ea5-8f3f-45f16cb3b28f
                Copyright 2024 Pettersen JH et al. JAMA Network Open.

                This is an open access article distributed under the terms of the CC-BY License.

                History
                : 4 March 2024
                : 15 May 2024
                Categories
                Research
                Original Investigation
                Online Only
                Public Health

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