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      Incidence of Inadvertent Intraoperative Hypothermia and Its Risk Factors in Patients Undergoing General Anesthesia in Beijing: A Prospective Regional Survey

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          Abstract

          Background/Objective

          Inadvertent intraoperative hypothermia (core temperature <36 0 C) is a recognized risk in surgery and has adverse consequences. However, no data about this complication in China are available. Our study aimed to determine the incidence of inadvertent intraoperative hypothermia and its associated risk factors in a sample of Chinese patients.

          Methods

          We conducted a regional cross-sectional survey in Beijing from August through December, 2013. Eight hundred thirty patients who underwent various operations under general anesthesia were randomly selected from 24 hospitals through a multistage probability sampling. Multivariate logistic regression analyses were applied to explore the risk factors of developing hypothermia.

          Results

          The overall incidence of intraoperative hypothermia was high, 39.9%. All patients were warmed passively with surgical sheets or cotton blankets, whereas only 10.7% of patients received active warming with space heaters or electric blankets. Pre-warmed intravenous fluid were administered to 16.9% of patients, and 34.6% of patients had irrigation of wounds with pre-warmed fluid. Active warming (OR = 0.46, 95% CI 0.26–0.81), overweight or obesity (OR = 0.39, 95% CI 0.28–0.56), high baseline core temperature before anesthesia (OR = 0.08, 95% CI 0.04–0.13), and high ambient temperature (OR = 0.89, 95% CI 0.79–0.98) were significant protective factors for hypothermia. In contrast, major-plus operations (OR = 2.00, 95% CI 1.32–3.04), duration of anesthesia (1–2 h) (OR = 3.23, 95% CI 2.19–4.78) and >2 h (OR = 3.44, 95% CI 1.90–6.22,), and intravenous un-warmed fluid (OR = 2.45, 95% CI 1.45–4.12) significantly increased the risk of hypothermia.

          Conclusions

          The incidence of inadvertent intraoperative hypothermia in Beijing is high, and the rate of active warming of patients during operation is low. Concern for the development of intraoperative hypothermia should be especially high in patients undergoing major operations, requiring long periods of anesthesia, and receiving un-warmed intravenous fluids.

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          Perioperative maintenance of normothermia reduces the incidence of morbid cardiac events. A randomized clinical trial.

          To assess the relationship between body temperature and cardiac morbidity during the perioperative period. Randomized controlled trial comparing routine thermal care (hypothermic group) to additional supplemental warming care (normothermic group). Operating rooms and surgical intensive care unit at an academic medical center. Three hundred patients undergoing abdominal, thoracic, or vascular surgical procedures who either had documented coronary artery disease or were at high risk for coronary disease. The relative risk of a morbid cardiac event (unstable angina/ischemia, cardiac arrest, or myocardial infarction) according to thermal treatment. Cardiac outcomes were assessed in a double-blind fashion. Mean core temperature after surgery was lower in the hypothermic group (35.4+/-0.1 degrees C) than in the normothermic group (36.7+/-0.1 degrees C) (P<.001) and remained lower during the early postoperative period. Perioperative morbid cardiac events occurred less frequently in the normothermic group than in the hypothermic group (1.4% vs 6.3%; P=.02). Hypothermia was an independent predictor of morbid cardiac events by multivariate analysis (relative risk, 2.2; 95% confidence interval, 1.1-4.7; P=.04), indicating a 55% reduction in risk when normothermia was maintained. Postoperative ventricular tachycardia also occurred less frequently in the normothermic group than in the hypothermic group (2.4% vs 7.9%; P=.04). In patients with cardiac risk factors who are undergoing noncardiac surgery, the perioperative maintenance of normothermia is associated with a reduced incidence of morbid cardiac events and ventricular tachycardia.
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            Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty.

            In-vitro studies indicate that platelet function and the coagulation cascade are impaired by hypothermia. However, the extent to which perioperative hypothermia influences bleeding during surgery remains unknown. Accordingly, we tested the hypothesis that mild hypothermia increases blood loss and allogeneic transfusion requirements during hip arthroplasty. Blood loss and transfusion requirements were evaluated in 60 patients undergoing primary, unilateral total hip arthroplasties who were randomly assigned to normothermia (final intraoperative core temperature 36.6 [0.4] degrees C) or mild hypothermia (35.0 [0.5] degrees C). Crystalloid, colloid, scavenged red cells, and allogeneic blood were administered by strict protocol. Intra- and postoperative blood loss was significantly greater in the hypothermic patients: 2.2 (0.5) L vs 1.7 (0.3) L, p < 0.001). Eight units of allogeneic packed red cells were required in seven of the 30 hypothermic patients, whereas only one normothermic patient required a unit of allogeneic blood (p < 0.05 for administered volume). A typical decrease in core temperature in patients undergoing hip arthroplasty will thus augment blood loss by approximately 500 mL. The maintenance of intraoperative normothermia reduces blood loss and allogeneic blood requirements in patients undergoing total hip arthroplasty.
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              Aggressive warming reduces blood loss during hip arthroplasty.

              We evaluated the effects of aggressive warming and maintenance of normothermia on surgical blood loss and allogeneic transfusion requirement. We randomly assigned 150 patients undergoing total hip arthroplasty with spinal anesthesia to aggressive warming (to maintain a tympanic membrane temperature of 36.5 degrees C) or conventional warming (36 degrees C). Autologous and allogeneic blood were given to maintain a priori designated hematocrits. Blood loss was determined by a blinded investigator based on sponge weight and scavenged cells; postoperative loss was determined from drain output. Results were analyzed on an intention-to-treat basis. Average intraoperative core temperatures were warmer in the patients assigned to aggressive warming (36.5 degrees +/- 0.3 degrees vs 36.1 degrees +/- 0.3 degrees C, P< 0.001). Mean arterial pressure was similar in each group preoperatively, but was greater intraoperatively in the conventionally warmed patients: 86+/-12 vs 80+/-9 mm Hg, P<0.001. Intraoperative blood loss was significantly greater in the conventional warming (618 mL; interquartile range, 480-864 mL) than the aggressive warming group (488 mL; interquartile range, 368-721 mL; P: = 0.002), whereas postoperative blood loss did not differ in the two groups. Total blood loss during surgery and over the first two postoperative days was also significantly greater in the conventional warming group (1678 mL; interquartile range, 1366-1965 mL) than in the aggressively warmed group (1,531 mL; interquartile range, 1055-1746 mL, P = 0.031). A total of 40 conventionally warmed patients required 86 units of allogeneic red blood cells, whereas 29 aggressively warmed patients required 62 units (P = 0.051 and 0.061, respectively). We conclude that aggressive intraoperative warming reduces blood loss during hip arthroplasty. Aggressive warming better maintained core temperature (36.5 degrees vs 36.1 degrees C) and slightly decreased intraoperative blood pressure. Aggressive warming also decreased blood loss by approximately 200 mL. Aggressive warming may thus, be beneficial in patients undergoing hip arthroplasty.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                11 September 2015
                2015
                : 10
                : 9
                : e0136136
                Affiliations
                [1 ]Peking Union Medical College Hospital, Beijing, China
                [2 ]3M China R&D Center, Shanghai, China
                [3 ]Plastic Surgery Hospital and Institute, CAMS, PUMC, Beijing, China
                [4 ]Tsinghua University Yuquan Hospital, Beijing, China
                [5 ]Beijing Chuiyangliu Hospital, Beijing, China
                [6 ]Beijing Chest Hospital, Capital Medical University, Beijing, China
                [7 ]Miyunxian Hospital, Beijing, China
                [8 ]Peking University Shougang Hospital, Beijing, China
                [9 ]China-Japan Friendship Hospital, Beijing, China
                [10 ]China Meitan General Hospital, Beijing, China
                [11 ]Peking University Third Hospital, Beijing, China
                [12 ]Beijing Tongren Hospital Capital Medical University, Beijing, China
                [13 ]Beijing Friendship Hospital, Capital Medical University, Beijing, China
                [14 ]Beijing Jishuitan Hospital, Beijing, China
                [15 ]Haidian Maternal & Child Health Hospital, Beijing, China
                [16 ]Xuanwu Hospital Capital Medical University, Beijing, China
                [17 ]Beijing Chao-Yang Hospital, Beijing, China
                [18 ]Luhe Teaching Hospital of the Capital Medical University, Beijing, China
                [19 ]Air Force General Hospital, PLA, Beijing, China
                [20 ]Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
                [21 ]Central Hospital of China Aerospace Corporation, Beijing, China
                [22 ]Beijing Rectum Hospital, Beijing, China
                [23 ]Beijing Shi Jing Shan Hospital, Beijing, China
                [24 ]Beijing Pinggu Hospital, Beijing, China
                [25 ]Beijing Hospital of the Ministry of Health, Beijing, China
                Massachusetts General Hospital, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Conceived and designed the experiments: JY ZYX MY YGH. Performed the experiments: JY ZYX XMD TF RQF WMG RHG NH CHL LL ML TZL MT GW LW TLW ASW DW XDX MJX XMY ZMY JHY QHZ GQZ MZZ SP YGH. Analyzed the data: JY ZYX LJZ MY YGH. Contributed reagents/materials/analysis tools: JY ZYX XMD TF RQF WMG RHG NH CHL LL ML TZL MT GW LW TLW ASW DW XDX MJX XMY ZMY JHY QHZ GQZ MZZ SP LJZ MY YGH. Wrote the paper: YGH JY ZYX XMD TF RQF WMG RHG NH CHL LL ML TZL MT GW LW TLW ASW DW XDX MJX XMY ZMY JHY QHZ GQZ MZZ SP LJZ MY. Manuscript Drafting: JY ZYX LJZ MY YGH. Manuscript Revision, Finalization and Approval: YGH JY ZYX XMD TF RQF WMG RHG NH CHL LL ML TZL MT GW LW TLW ASW DW XDX MJX XMY ZMY JHY QHZ GQZ MZZ SP LJZ MY. Study Administration: JY YGH. Funding: YGH.

                Article
                PONE-D-15-17034
                10.1371/journal.pone.0136136
                4567074
                26360773
                afe964fd-8e47-464e-94a2-d1ae4343e312
                Copyright @ 2015

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

                History
                : 11 May 2015
                : 24 July 2015
                Page count
                Figures: 1, Tables: 3, Pages: 12
                Funding
                This study was funded by the China National Health and Planned Parenthood Committee Health Quality Improvement Award (ID# 201402017, principle investigator Yuguang Huang, MD), China National Nature Science Foundation (Grant# 31070930, principle investigator Yuguang Huang, MD), and an unrestricted research grant (MDI0077, principle investigator Yuguang Huang, MD) from 3M China.
                Categories
                Research Article
                Custom metadata
                Due to ethical restrictions, data are available from the Peking Union Medical College Hospital Institutional Data Access / Ethics Committee. Interested researchers may contact Prof Jie Chen, Chair of PUMC IRB, and submit an application form. For more information, please visit ( http://www.pumch.cn).

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