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      Enhancing antioxidant delivery through 3D printing: a pathway to advanced therapeutic strategies

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          Abstract

          The rapid advancement of 3D printing has transformed industries, including medicine and pharmaceuticals. Integrating antioxidants into 3D-printed structures offers promising therapeutic strategies for enhanced antioxidant delivery. This review explores the synergistic relationship between 3D printing and antioxidants, focusing on the design and fabrication of antioxidant-loaded constructs. Incorporating antioxidants into 3D-printed matrices enables controlled release and localized delivery, improving efficacy while minimizing side effects. Customization of physical and chemical properties allows tailoring of antioxidant release kinetics, distribution, and degradation profiles. Encapsulation techniques such as direct mixing, coating, and encapsulation are discussed. Material selection, printing parameters, and post-processing methods significantly influence antioxidant release kinetics and stability. Applications include wound healing, tissue regeneration, drug delivery, and personalized medicine. This comprehensive review aims to provide insights into 3D printing-assisted antioxidant delivery systems, facilitating advancements in medicine and improved patient outcomes for oxidative stress-related disorders.

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          Hydrogels with tunable stress relaxation regulate stem cell fate and activity

          Ovijit Chaudhuri, Luo Gu, Darinka Klumpers … (2015)
          Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic. Here, we report a materials approach to tune the rate of stress relaxation of hydrogels for 3D culture, independently of the hydrogel’s initial elastic modulus, cell-adhesion-ligand density and degradation. We find that cell spreading, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) are all enhanced in cells cultured in gels with faster relaxation. Strikingly, MSCs form a mineralized, collagen-1-rich matrix similar to bone in rapidly relaxing hydrogels with an initial elastic modulus of 17 kPa. We also show that the effects of stress relaxation are mediated by adhesion-ligand binding, actomyosin contractility and mechanical clustering of adhesion ligands. Our findings highlight stress relaxation as a key characteristic of cell-ECM interactions and as an important design parameter of biomaterials for cell culture.
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            Natural Antioxidants: Sources, Compounds, Mechanisms of Action, and Potential Applications

            M.S. Brewer (2011)
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              Laser additive manufacturing of metallic components: materials, processes and mechanisms

              D Gu, W MEINERS, Dirk Wissenbach … (2013)
              Article 0 comments Cited 231 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Ageel Alogla: URI : https://loop.frontiersin.org/people/2372073/overviewRole: Role: Role: Role: Role: Role: Role: Role:
                Journal
                Journal ID (nlm-ta): Front Bioeng Biotechnol
                Journal ID (iso-abbrev): Front Bioeng Biotechnol
                Journal ID (publisher-id): Front. Bioeng. Biotechnol.
                Title: Frontiers in Bioengineering and Biotechnology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2296-4185
                Publication date (Electronic): 04 October 2023
                Publication date Collection: 2023
                Volume: 11
                Electronic Location Identifier: 1256361
                Affiliations
                Industrial Engineering Department , College of Engineering (AlQunfudhah) , Umm Al-Qura University , Mecca, Saudi Arabia
                Author notes

                Edited by: Dennis Douroumis, University of Greenwich, United Kingdom

                Reviewed by: Sara Maria Giannitelli, Campus Bio-Medico University, Italy

                Christina Karavasili, Aristotle University of Thessaloniki, Greece

                *Correspondence: Ageel Alogla, aaogla@ 123456uqu.edu.sa
                Article
                Publisher ID: 1256361
                DOI: 10.3389/fbioe.2023.1256361
                PMC ID: 10583562
                PubMed ID: 37860625
                SO-VID: af0ea096-cd9c-40ce-b3aa-212ccd219d0f
                Copyright © Copyright © 2023 Alogla.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 11 July 2023
                Date accepted : 22 September 2023
                Funding
                The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
                Categories
                Subject: Bioengineering and Biotechnology
                Subject: Review
                Custom metadata
                section-at-acceptance Nanobiotechnology

                Keywords: 3d printing,antioxidants,oxidative stress-related disorders,therapeutic strategies,controlled release
                Data availability:
                Keywords: 3d printing, antioxidants, oxidative stress-related disorders, therapeutic strategies, controlled release

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