For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
9
views
36
references
 Top references
cited by
5
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
2 collections
    0
    shares
      163
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Systems science approaches to cardiovascular disease prevention and management in the era of COVID-19: A Humpty-Dumpty dilemma?

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The coronavirus disease 2019 (COVID-19) pandemic necessitated the implementation and prioritizing of strict public health strategies to mitigate COVID-19 transmission and infection over all else. As we enter a ‘recovery’ phase in which the impact of the virus recedes (but does not relent), we ask, “ How do we develop a game plan that considers prevention over management of public health threats of a more chronic nature, including cardiovascular disease? ” We frame this choice point as a “Humpty-Dumpty” moment for public health with enduring and potentially irreversible consequences. Citing clear examples of other public health successes and failures, we outline in detail how sustaining cardiovascular population health under complex post-pandemic conditions will necessitate decision-making to be informed with a systems science approach, in which interventions, goals, outcomes and features of complex systems are carefully aligned.

          Related collections

          Most cited references36

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Changes in physical activity and sedentary behaviours from before to during the COVID-19 pandemic lockdown: a systematic review

          Stephanie Stockwell, Mike Trott, Mark Tully … (2021)
          Objective In March 2020, several countries banned unnecessary outdoor activities during COVID-19, commonly called ‘lockdowns. These lockdowns have the potential to impact associated levels of physical activity and sedentary behaviour. Given the numerous health outcomes associated with physical activity and sedentary behaviour, the aim of this review was to summarise literature that investigated differences in physical activity and sedentary behaviour before vs during the COVID-19 lockdown. Design, data sources and eligibility criteria Electronic databases were searched from November 2019 to October 2020 using terms and synonyms relating to physical activity, sedentary behaviour and COVID-19. The coprimary outcomes were changes in physical activity and/or sedentary behaviour captured via device-based measures or self-report tools. Risk of bias was measured using the Newcastle-Ottawa Scale. Results Sixty six articles met the inclusion criteria and were included in the review (total n=86 981). Changes in physical activity were reported in 64 studies, with the majority of studies reporting decreases in physical activity and increases in sedentary behaviours during their respective lockdowns across several populations, including children and patients with a variety of medical conditions. Conclusion Given the numerous physical and mental benefits of increased physical activity and decreased sedentary behaviour, public health strategies should include the creation and implementation of interventions that promote safe physical activity and reduce sedentary behaviour should other lockdowns occur.
          Article 0 comments Cited 442 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found

            Effects of stress on the development and progression of cardiovascular disease

            Mika Kivimäki, Andrew Steptoe (2018)
            Cardiovascular disease remains the leading cause of disease burden globally, which underlies the continuing need to identify new complementary targets for prevention. Over the past 5-10 years, the pooling of multiple data sets into 'mega-studies' has accelerated progress in research on stress as a risk and prognostic factor for cardiovascular disease. Severe stressful experiences in childhood, such as physical abuse and household substance abuse, can damage health and increase the risk of multiple chronic conditions in adulthood. Compared with childhood stress and adulthood classic risk factors, such as smoking, high blood pressure, and high serum cholesterol levels, the harmful effects of stress in adulthood are generally less marked. However, adulthood stress has an important role as a disease trigger in individuals who already have a high atherosclerotic plaque burden, and as a determinant of prognosis and outcome in those with pre-existing cardiovascular or cerebrovascular disease. In real-life settings, mechanistic studies have corroborated earlier laboratory-based observations on stress-related pathophysiological changes that underlie triggering, such as lowered arrhythmic threshold and increased sympathetic activation with related increases in blood pressure, as well as pro-inflammatory and procoagulant responses. In some clinical guidelines, stress is already acknowledged as a target for prevention for people at high overall risk of cardiovascular disease or with established cardiovascular disease. However, few scalable, evidence-based interventions are currently available.
            Article 0 comments Cited 309 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment

              Anant Parasher (2020)
              Background The severe acute respiratory syndrome (SARS) coronavirus-2 is a novel coronavirus belonging to the family Coronaviridae and is now known to be responsible for the outbreak of a series of recent acute atypical respiratory infections originating in Wuhan, China. The disease caused by this virus, termed coronavirus disease 19 or simply COVID-19, has rapidly spread throughout the world at an alarming pace and has been declared a pandemic by the WHO on March 11, 2020. In this review, an update on the pathophysiology, clinical presentation and the most recent management strategies for COVID-19 has been described. Materials and Methods A search was conducted for literature and various articles/case reports from 1997 to 2020 in PUBMED/MEDLINE for the keywords coronavirus, SARS, Middle East respiratory syndrome and mRNA virus. Results and Conclusions COVID-19 has now spread globally with increasing morbidity and mortality among all populations. In the absence of a proper and effective antibody test, the diagnosis is presently based on a reverse-transcription PCR of nasopharyngeal and oropharyngeal swab samples. The clinical spectrum of the disease presents in the form of a mild, moderate or severe illness. Most patients are either asymptomatic carriers who despite being without symptoms have the potential to be infectious to others coming in close contact, or have a mild influenza-like illness which cannot be differentiated from a simple upper respiratory tract infection. Moderate and severe cases require hospitalisation as well as intensive therapy which includes non-invasive as well as invasive ventilation, along with antipyretics, antivirals, antibiotics and steroids. Complicated cases may require treatment by immunomodulatory drugs and plasma exchange therapy. The search for an effective vaccine for COVID-19 is presently in full swing, with pharmaceutical corporations having started human trials in many countries.
              Article 0 comments Cited 248 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Prog Cardiovasc Dis
                Journal ID (iso-abbrev): Prog Cardiovasc Dis
                Title: Progress in Cardiovascular Diseases
                Publisher: Elsevier Inc.
                ISSN (Print): 0033-0620
                ISSN (Electronic): 1873-1740
                Publication date PMC-release: 20 December 2022
                Publication date (Electronic): 20 December 2022
                Affiliations
                [a ]HealthPartners Institute, Minneapolis, MN, USA
                [b ]Department of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA
                [c ]Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA
                [d ]Department of Biomedical and Health Information Sciences, University of Illinois at Chicago, Chicago, USA
                [e ]Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA
                [f ]Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, USA
                [g ]Biomedical Research Theme, School of Human Sciences, University of Derby, UK
                Author notes
                [* ]Corresponding author at: HealthPartners Institute, 8170 33rd Avenue South, Minneapolis, MN 55425, USA.
                Article
                Publisher Item ID: S0033-0620(22)00155-4
                DOI: 10.1016/j.pcad.2022.12.003
                PMC ID: 9764826
                SO-VID: af0053fc-cda2-489d-9682-cba06b1e1f6a
                Copyright © © 2022 Elsevier Inc. All rights reserved.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Categories
                Subject: Article

                Keywords: prevention,management,cardiovascular disease,covid-19,systems science,complexity,cbpr, community-based participatory research,covid-19, coronavirus disease 2019,crc, colorectal cancer,cvd, cardiovascular disease,dsm, dynamic simulation model,gmb, group model building,hedis, healthcare effectiveness data information set,pa, physical activity,sars-cov-2, coronavirus disease
                Data availability:
                Keywords: prevention, management, cardiovascular disease, covid-19, systems science, complexity, cbpr, community-based participatory research, covid-19, coronavirus disease 2019, crc, colorectal cancer, cvd, cardiovascular disease, dsm, dynamic simulation model, gmb, group model building, hedis, healthcare effectiveness data information set, pa, physical activity, sars-cov-2, coronavirus disease

                Comments

                Comment on this article

                scite_

                Similar content163

                See all similar

                Cited by5

                See all cited by

                Most referenced authors724

                See all reference authors