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      Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies.

      1 , 2
      Critical reviews in oncogenesis

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          Abstract

          Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the genetic, epigenetic, and biological complexities of this rare tumor. In this review we provide a general background on the biology of osteosarcoma and the clinical status quo. We go on to enumerate the genetic and epigenetic defects identified in osteosarcoma. Finally, we discuss ongoing large-scale studies in the field and potential new therapies that are currently under investigation.

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          Author and article information

          Journal
          Crit Rev Oncog
          Critical reviews in oncogenesis
          0893-9675
          0893-9675
          2015
          : 20
          : 3-4
          Affiliations
          [1 ] Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
          [2 ] Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
          Article
          3952f49a3022a411,6df584a0063de289 NIHMS790570
          10.1615/CritRevOncog.2015013713
          4894524
          26349415
          aec842c2-c3b6-435d-aa82-d8fa6a6d21b7
          History

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