34
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Dietary nitrate (NO 3 ) has been shown to be useful as an ergogenic aid with potential applications in health and disease (e.g., blood pressure control). However, there is no consensus about the effects of dietary NO 3 or beetroot (BR) juice supplementation on cognitive function.

          Objective

          The aim of this study was to evaluate the effects of a single dose of a chewable BR-based supplement on cognitive performance.

          Methods

          A double-blind randomized placebo-controlled two-period crossover clinical trial was carried out based on the extension of the CONSORT guidelines for randomized crossover trials. A total of 44 participants (24 F; 20 M; 32.7 [12.5] years; 66.3 [9.0] kg; 170 [9.2] cm; 22.8 [1.4] kg/m 2) were randomly allocated to receive first either four BR-based chewable tablets (BR-CT) containing 3 g of a Beta vulgaris extract (RedNite ®) or four tablets of a placebo (maltodextrin). A 4-day washout period was used before crossover. Ninety minutes after ingestion of the treatments, a neuropsychological testing battery was administered in each period. The trial was registered at clinicaltrials.gov NCT05509075.

          Results

          Significant improvements with moderate effect size were found on memory consolidation at the short and long term only after BR-CT supplementation via the Rey Auditory Verbal Learning Test immediate (+ 20.69%) and delayed (+ 12.34%) recalls. Likewise, enhancement on both frontal lobe functions (+ 2.57%) and cognitive flexibility (+ 11.16%) were detected after BR-CT. There was no significant change ( p < 0.05) on verbal memory of short-term digits, working memory and information processing speed. Mixed results were found on mood and anxiety through the Beck Depression Inventory-II (BDI-II) and the State-Trait Anxiety Inventory (STAI-Y1 and STAI-Y2); however, sequence and period effects were seen on STAI-Y2.

          Conclusions

          The acute administration of a chewable BR-based supplement improves certain aspects of cognitive function in healthy females and males, particularly memory capacity and frontal skills.

          Related collections

          Most cited references77

          • Record: found
          • Abstract: found
          • Article: not found

          Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients.

          The amended (revised) Beck Depression Inventory (BDI-IA; Beck & Steer, 1993b) and the Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) were self-administered to 140 psychiatric outpatients with various psychiatric disorders. The coefficient alphas of the BDI-IA and the BDI-II were, respectively, .89 and .91. The mean rating for Sadness on the BDI-IA was higher than it was on the BDI-II, but the mean ratings for Past Failure, Self-Dislike, Change in Sleeping Pattern, and Change in Appetite were higher on the BDI-II than they were on the BDI-IA. The mean BDI-II total score was approximately 2 points higher than it was for the BDI-IA, and the outpatients also endorsed approximately one more symptom on the BDI-II than they did on the BDI-IA. The correlations of BDI-IA and BDI-II total scores with sex, ethnicity, age, the diagnosis of a mood disorder, and the Beck Anxiety Inventory (Beck & Steer, 1993a) were within 1 point of each other for the same variables.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            CONSORT 2010 statement: extension to randomised crossover trials

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Cognitive Neuroscience and the Study of Memory

                Bookmark

                Author and article information

                Contributors
                rcannataro@nutrics.it
                Journal
                Eur J Nutr
                Eur J Nutr
                European Journal of Nutrition
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                1436-6207
                1436-6215
                24 October 2023
                24 October 2023
                2024
                : 63
                : 1
                : 303-321
                Affiliations
                [1 ]Department of Medical and Surgical Sciences, University of Magna Graecia, ( https://ror.org/0530bdk91) Catanzaro, Italy
                [2 ]BEAMS Department, Universitè Libre de Bruxelles, ( https://ror.org/01r9htc13) Brussels, Belgium
                [3 ]Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, ( https://ror.org/02rc97e94) Rende, Italy
                [4 ]Galascreen Laboratories, University of Calabria, ( https://ror.org/02rc97e94) Rende, Italy
                [5 ]GRID grid.411489.1, ISNI 0000 0001 2168 2547, Clinical Pharmacology and Pharmacovigilance Operative Unit, Department of Health Science, , University of Magna Graecia, Mater Domini Hospital, ; Catanzaro, Italy
                [6 ]Research Division, Dynamical Business and Science Society–DBSS International SAS, 110861 Bogotá, Colombia
                [7 ]Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, ( https://ror.org/04nmbd607) 230002 Montería, Colombia
                [8 ]Research Group in Biochemistry and Molecular Biology, Universidad Distrital Francisco José de Caldas, ( https://ror.org/02jsxd428) 110311 Bogotá, Colombia
                Author information
                http://orcid.org/0000-0002-1668-7690
                Article
                3265
                10.1007/s00394-023-03265-y
                10799154
                37875637
                ae7e46fa-335f-41eb-8501-82afdf27c2a3
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 4 September 2022
                : 3 October 2023
                Categories
                Original Contribution
                Custom metadata
                © Springer-Verlag GmbH Germany, part of Springer Nature 2024

                Nutrition & Dietetics
                nitric oxide,nitrates,dietary supplements,neuropsychological tests,cognitive function

                Comments

                Comment on this article