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Cholangiocarcinoma
Author(s):
Nataliya Razumilava
,
Gregory J Gores
Publication date
Created:
June 2014
Publication date
(Print):
June 2014
Journal:
The Lancet
Publisher:
Elsevier BV
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Abstract
Cholangiocarcinoma represents a diverse group of epithelial cancers united by late diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are undertaken for cholangiocarcinomas of different anatomical locations (intrahepatic, perihilar, and distal). Mixed hepatocellular cholangiocarcinomas have emerged as a distinct subtype of primary liver cancer. Clinicians need to be aware of intrahepatic cholangiocarcinomas arising in cirrhosis and properly assess liver masses in this setting for cholangiocarcinoma. Management of biliary obstruction is obligatory in perihilar cholangiocarcinoma, and advanced cytological tests such as fluorescence in-situ hybridisation for aneusomy are helpful in the diagnosis. Liver transplantation is a curative option for selected patients with perihilar but not with intrahepatic or distal cholangiocarcinoma. International efforts of clinicians and scientists are helping to identify the genetic drivers of cholangiocarcinoma progression, which will unveil early diagnostic markers and direct development of individualised therapies. Copyright © 2014 Elsevier Ltd. All rights reserved.
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Author and article information
Journal
Title:
The Lancet
Abbreviated Title:
The Lancet
Publisher:
Elsevier BV
ISSN (Print):
01406736
Publication date Created:
June 2014
Publication date (Print):
June 2014
Volume
: 383
Issue
: 9935
Pages
: 2168-2179
Article
DOI:
10.1016/S0140-6736(13)61903-0
PMC ID:
4069226
PubMed ID:
24581682
SO-VID:
ad8af89b-bb2c-49fe-b8dd-c46b7669c50f
Copyright ©
© 2014
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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