Increased risk of peripheral arterial occlusive disease in patients with Bell's palsy using population data

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Objective

This population-based cohort study investigated the risk of developing peripheral arterial occlusive disease (PAOD) in patients with Bell’s palsy.

Methods

We used longitudinal claims data of health insurance of Taiwan to identify 5,152 patients with Bell’s palsy newly diagnosed in 2000–2010 and a control cohort of 20,608 patients without Bell’s palsy matched by propensity score. Incidence and hazard ratio (HR) of PAOD were assessed by the end of 2013.

Results

The incidence of PAOD was approximately 1.5 times greater in the Bell’s palsy group than in the non-Bell’s palsy controls (7.75 vs. 4.99 per 1000 person-years). The Cox proportional hazards regression analysis measured adjusted HR was 1.54 (95% confidence interval (CI) = 1.35–1.76) for the Bell’s palsy group compared to the non-Bell’s palsy group, after adjusting for sex, age, occupation, income and comorbidities. Men were at higher risk of PAOD than women in the Bell’s palsy group, but not in the controls. The incidence of PAOD increased with age in both groups, but the Bell’s palsy group to control group HR of PAOD decreased as age increased. The systemic steroid treatment reduced 13% of PAOD hazard for Bell’s palsy patients, compared to those without the treatment, but not significant.

Conclusions

Bell’s palsy appears to be associated with an increased risk of developing PAOD. Further pathophysiologic, histopathology and immunologic research is required to explore the underlying biologic mechanism.

Related collections

Most cited references 26

Record: found
Abstract: found
Article: not found

Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000.

Elizabeth Selvin, Thomas Erlinger (2004)

Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely. We analyzed data from 2174 participants aged 40 years and older from the 1999-2000 National Health and Nutrition Examination Survey. PAD was defined as an ankle-brachial index <0.90 in either leg. The prevalence of PAD among adults aged 40 years and over in the United States was 4.3% (95% CI 3.1% to 5.5%), which corresponds to approximately 5 million individuals (95% CI 4 to 7 million). Among those aged 70 years or over, the prevalence was 14.5% (95% CI 10.8% to 18.2%). In age- and gender-adjusted logistic regression analyses, black race/ethnicity (OR 2.83, 95% CI 1.48 to 5.42) current smoking (OR 4.46, 95% CI 2.25 to 8.84), diabetes (OR 2.71, 95% CI 1.03 to 7.12), hypertension (OR 1.75, 95% CI 0.97 to 3.13), hypercholesterolemia (OR 1.68, 95% CI 1.09 to 2.57), and low kidney function (OR 2.00, 95% CI 1.08 to 3.70) were positively associated with prevalent PAD. More than 95% of persons with PAD had 1 or more cardiovascular disease risk factors. Elevated fibrinogen and C-reactive protein levels were also associated with PAD. This study provides nationally representative prevalence estimates of PAD in the United States, revealing that PAD affects more than 5 million adults. PAD prevalence increases dramatically with age and disproportionately affects blacks. The vast majority of individuals with PAD have 1 or more cardiovascular disease risk factors that should be targeted for therapy.

0 comments Cited 361 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Bell palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle.

N Hato, N Yanagihara, T Doi … (1996)

To determine whether herpes simplex virus type 1 (HSV-1) causes Bell palsy. Prospective study. University inpatient service. 14 patients with Bell palsy, 9 patients with the Ramsay-Hunt syndrome, and 12 other controls. Viral genomes of HSV-1, varicella-zoster virus, and Epstein-Barr virus were analyzed in clinical samples of facial nerve endoneurial fluid and posterior auricular muscle using polymerase chain reaction (PCR) followed by hybridization with Southern blot analysis. Herpes simplex virus type 1 genomes were detected in 11 of 14 patients (79%) with Bell palsy but not in patients with the Ramsay-Hunt syndrome or in other controls. The nucleotide sequences of the PCR fragments were identical to those of the HSV-1 genome. Herpes simplex virus type 1 is the major etiologic agent in Bell palsy.

0 comments Cited 88 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Clinical practice. Bell's Palsy.

D H Gilden (2004)

0 comments Cited 79 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Li-Syue Liou: Role: ConceptualizationRole: Writing – original draftRole: Writing – review & editing

Chih-Ya Chang: Role: ConceptualizationRole: Writing – review & editing

Hsuan-Ju Chen: Role: Formal analysis

Chun-Hung Tseng: Role: ConceptualizationRole: Validation

Cheng-Yu Chen: Role: Writing – review & editing

Fung-Chang Sung:

ORCID: http://orcid.org/0000-0002-8377-0398

Role: MethodologyRole: Writing – review & editing

Yoshiaki Taniyama: Role: Editor

Journal

Journal ID (nlm-ta): PLoS One

Journal ID (iso-abbrev): PLoS ONE

Journal ID (publisher-id): plos

Journal ID (pmc): plosone

Title: PLoS ONE

Publisher: Public Library of Science (San Francisco, CA USA )

ISSN (Electronic): 1932-6203

Publication date (Electronic): 7 December 2017

Publication date Collection: 2017

Volume: 12

Issue: 12

Electronic Location Identifier: e0188982

Affiliations

[1 ] Department of Family Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien City, Hualien County, Taiwan, ROC

[2 ] Department of Family Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Xindian Dist., New Taipei City, Taiwan(R.O.C)

[3 ] Department of Family and Community Medicine, Tri-Service General Hospital, Neihu District, Taipei City, Taiwan(R.O.C.)

[4 ] School of Medicine, National Defense Medical Center, Neihu Dist., Taipei City, aiwan (R.O.C.)

[5 ] Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, Neihu District, Taipei City, Taiwan(R.O.C.)

[6 ] Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan, Taichung, Taichung, Taiwan (R.O.C.)

[7 ] Department of Neurology, China Medical University Hospital, Taichung, Taiwan, North District, Taichung, Taiwan (R.O.C.)

[8 ] School of Medicine, China Medical University, Taichung, Taiwan, Taichung, Taichung, Taiwan (R.O.C.)

[9 ] Graduate Institute of Clinical Medicine Science, College of Medicine, China Medical University, Taichung, Taiwan; Taichung, Taichung, Taiwan (R.O.C.)

[10 ] Department of Health Services Administration, China Medical University, Taichung, Taiwan; Taichung, Taichung, Taiwan (R.O.C.)

Osaka University Graduate School of Medicine, JAPAN

Author notes

Competing Interests: The authors have declared that no competing interests exist.

* E-mail: fcsung1008@ 123456yahoo.com

Author information

Fung-Chang Sung http://orcid.org/0000-0002-8377-0398

Article

Publisher ID: PONE-D-17-24757

DOI: 10.1371/journal.pone.0188982

PMC ID: 5720702

PubMed ID: 29216223

SO-VID: ad720062-30e5-4f5c-b614-7c7d8c471989

License:

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

History

Date received : 30 June 2017

Date accepted : 16 November 2017

Page count

Figures: 1, Tables: 4, Pages: 11