Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis.

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Abstract

Asparaginyl endopeptidase (AEP) has been implicated in human cancer development. However, the molecular mechanisms underlying AEP regulation, including the role of pro-AEP activation, remain elusive.

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Journal

Journal ID (iso-abbrev): J. Natl. Cancer Inst.

Title: Journal of the National Cancer Institute

ISSN (Electronic): 1460-2105

ISSN (Print): 0027-8874

Publication date (Electronic): Apr 2014

Volume: 106

Issue: 4

Affiliations

[1 ] Affiliations of authors: Laboratory of Targeted Tumor Therapy, Key Laboratory of Systems Biology, Shanghai Advanced Research Institute (QL, BP, CW, YZ, FG) Institute of Health Sciences (YL, XC, BL, FG) Chinese Academy of Sciences, Shanghai, China; Department of Neurosurgery, Renji Hospital (YQ,YL) Shanghai First People's Hospital (YG) and Department of Radiation Oncology, Ruijin Hospital (CX), School of Medicine, Shanghai Jiao-Tong University, Shanghai, China; Scripps Research Institute, La Jolla, CA (GFK, TSE); Sorrento Thearpeutics, Inc, San Diego, CA (GFK); Department of Neuro-Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX (ZL); Cancer Research Center, Shenzhen University, Shenzhen, China (DL); Shanghai Institute for Advanced Immunochemical Studies, Shanghai Tech University, Shanghai, China (BJ).

Article

Publisher Item ID: dju012

DOI: 10.1093/jnci/dju012

PubMed ID: 24610907

SO-VID: ad35d18d-d061-42db-8471-97cbcebff434

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