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      Efecto hepatoprotector del extracto hidroetanólico atomizado del maíz morado (Zea mays L.) en lesiones hepáticas inducidas en ratas Translated title: Hepatoprotective effect of atomized hydroethanolic extract from Andean purple corn (Zea mays L.) in induced hepatic injury in rats

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          Abstract

          Objetivos: Evaluar el efecto hepatoprotector del extracto hidroetanólico atomizado de Zea mays variedad morado sobre lesiones hepáticas inducidas en ratas. Diseño: Experimental. Institución: Laboratorio de Farmacología Experimental, Facultad de Medicina Humana, Universidad Nacional Mayor de San Marcos, Lima, Perú. Material biológico: Extracto hidroetanólico atomizado de maíz morado (EAM). Intervenciones: Se formó seis grupos de ratas machos (n=10, por cada grupo), se les administró fenobarbital a concentración de 0,5 g/L en agua potable ad líbitum por 15 días; posteriormente se administró tetracloruro de carbono (CCl) a una dosis de 0,2 mL/kg, por vía oral. El diseño experimental fue el siguiente: G1: suero fisiológico (SSF); G2: CCl0,2 mL/kg (T);4G3: T+ 4 silimarina 25 mg/kg; G4: T + EAM 500 mg/kg; G5: T + EAM 1 000 mg/kg; G6: T + EAM 2 000 mg/kg. Principales medidas de resultados: Perfil hepático, especies reactivas al ácido tiobarbitúrico (TBARS) en suero, índice hepático, observación histológica. Resultados: Se observó aumento significativo (p<0,05) en la actividad de alanina amino transferasa (ALT) entre el grupo G2 y los grupos G3 y G4 (p<0,001). Hubo disminución significativa (p<0,05) de fosfatasa alcalina (FAL) en el grupo G2 con respecto G1. El nivel de TBARS fue menor en el grupo que recibió 1 000 mg/kg de EAM con respecto al control. Las actividades de HDL-C y triglicéridos no mostraron diferencias significativas. Se ha observado la reducción de 60% de la lesión hepática, evidenciado con menor daño del hepatocito al estudio histológico. Conclusiones: El extracto hidroetanólico atomizado de maíz morado a la dosis de 1 000 mg/kg disminuyó las lesiones hepáticas inducidas en ratas.

          Translated abstract

          Objectives: To evaluate the hepatoprotector effect of hydroalcoholic extract atomized of Zea mays against hepatic injuries induced in rats. Design: Experimental. Institution: Laboratory of Experimental Pharmacology, Faculty of Human Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Hydroethanolic extract atomized of purple corn (EAM). Interventions: To six groups of male rats (n = 10, for each group) phenobarbital 0.5 g/L in drinkable water ad libitum was administered for 15 days, followed by carbon tetrachloride 0.2 mL/kg p.o. The experimental design was a follow: G1: normal; G2: CCl4 0.2 mL/kg (T); G3:T+ silimarina 25 mg/kg; G4: T+ EAM 500 mg/kg; G5: T + EAM 1 000 mg/kg; G6 T + EAM 2 000 mg/kg. Main outcome measures: Hepatic profile, reactive species to thiobarbituric acid (TBARS), liver index, and histological observation. Results: Significant increase (p<0.05) in ALT activity was observed between group G2 in comparison to groups G3 and G4 (p<0,001). There was significant decrease (p < 0.05) of alkaline phosphatase (AP) in group G2 with respect to G1. TBARS level was less in the group that received 1 000 mg/kg of EAM regarding to control. HDL-C and triglycerides activities did not show significant differences. Reduction in 60% of hepatic injury was observed, evidencing less damage of the hepatocyte by histological study. Conclusions: The purple corn atomized hydroethanolic extract at 1 000 mg/kg dose decreased induced hepatic injuries in rats.

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          Author and article information

          Contributors
          Role: ND
          Role: ND
          Role: ND
          Role: ND
          Journal
          afm
          Anales de la Facultad de Medicina
          An. Fac. med.
          Universidad Nacional Mayor de San Marcos. Facultad de Medicina (Lima )
          1025-5583
          April 2015
          : 76
          : 2
          : 123-128
          Affiliations
          [1 ] Universidad Nacional Mayor de San Marcos Perú
          [2 ] Universidad Nacional Mayor de San Marcos Perú
          [3 ] Universidad Nacional Mayor de San Marcos Perú
          [4 ] Universidad Nacional San Luis Gonzaga Perú
          Article
          S1025-55832015000300003
          10.15381/anales.v76i2.11136
          acf15904-09c9-403f-b76f-cd10ccf40591

          http://creativecommons.org/licenses/by/4.0/

          History
          Categories
          HEALTH CARE SCIENCES & SERVICES
          HEALTH POLICY & SERVICES
          INTEGRATIVE & COMPLEMENTARY MEDICINE
          MEDICAL ETHICS
          MEDICAL LABORATORY TECHNOLOGY
          MEDICINE, GENERAL & INTERNAL
          MEDICINE, LEGAL
          MEDICINE, RESEARCH & EXPERIMENTAL
          PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

          Social law,General medicine,Medicine,Clinical chemistry,Internal medicine,Complementary & Alternative medicine,Health & Social care,Public health
          hepatomegaly,Zea mays L,liver injury,medicinal plant,lesión hepática,hepatomegalia,planta medicinal

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