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      Structures and cytotoxicities of three new sesquiterpenes from cultures of Armillaria sp.

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          Abstract

          Abstract

          Three new sesquiterpene aryl esters, named 10-dehydroxy-melleoliede B ( 1), 1- O-formyl-10-dehydroxy-melleoliede B ( 2) and 10-oxo-melleoliede B ( 3) together with six known ones ( 49), were isolated from the cultures of Armillaria sp. The structures of the new compounds were elucidated based on the extensive spectroscopic methods. Compounds 1, 2, and 59 exhibited moderate cytotoxicities.

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          Supplementary material is available for this article at 10.1007/s13659-012-0077-1 and is accessible for authorized users.

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          Pigments of fungi (macromycetes).

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            Evidence for the natural toxins from the mushroom Trogia venenata as a cause of sudden unexpected death in Yunnan Province, China.

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              In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects.

              Melleolide sesquiterpene aryl esters are secondary products of the mushroom genus Armillaria. We compared the cytotoxicity of eleven melleolides--five thereof are new natural products--against four human cancer cell lines. Armillaridin, 4-O-methylarmillaridin, and dehydroarmillylorsellinate were most active, at IC(50) = 3.0, 4.1 and 5.0 μM, respectively, against Jurkat T cells for the former two compounds, and K-562 cells for the latter. Dehydroarmillylorsellinate did not inhibit respiration and RNA-synthesis of K-562 cells at 5 μM. However, replication of DNA dropped to 35% after 120 min at this concentration, and translational activity also decreased.
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                Author and article information

                Contributors
                jkliu@mail.kib.ac.cn
                Journal
                Nat Prod Bioprospect
                Nat Prod Bioprospect
                Natural Products and Bioprospecting
                Springer-Verlag (Berlin/Heidelberg )
                2192-2195
                2192-2209
                20 December 2012
                20 December 2012
                December 2012
                : 2
                : 6
                : 245-248
                Affiliations
                [ ]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China
                [ ]University of Chinese Academy of Sciences, Beijing, 100049 China
                Article
                77
                10.1007/s13659-012-0077-1
                4131607
                ace0bc9f-deb0-442f-841b-ea1acd13f3e2
                © The Author(s) 2012
                History
                : 29 September 2012
                : 25 October 2012
                Categories
                Regular Article
                Custom metadata
                © The Author(s) 2012

                basidiomycete,armillaria sp.,sesquiterpene aryl ester,cytotoxicities

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