Mutations in GAS5 affect the transformation from benign prostate proliferation to aggressive prostate cancer by affecting the transcription efficiency of GAS5.

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Abstract

In this study, we aimed to explore the effects of GAS5 single-nucleotide polymorphisms (SNPs) on GAS5 expression. And the signaling pathways underlying the function of GAS5 during the pathogenesis of prostate cancer (PC) were clarified.

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Journal

Journal ID (iso-abbrev): J. Cell. Physiol.

Title: Journal of cellular physiology

Publisher: Wiley

ISSN (Electronic): 1097-4652

ISSN (Print): 0021-9541

Publication date (Electronic): Jun 2019

Volume: 234

Issue: 6

Affiliations

[1 ] Department of Urology, People's Hospital of Ruian, Ruian, Zhejiang, China.

[2 ] Department of Hand Surgery, People's Hospital of Ruian, Ruian, Zhejiang, China.

[3 ] Department of Pediatrics, People's Hospital of Ruian, Ruian, Zhejiang, China.

Article

DOI: 10.1002/jcp.27561

PubMed ID: 30317620

SO-VID: acbf5831-311d-4c08-a583-6ef812277016

History

Keywords: PTEN,apoptosis,PDCD4,GAS5,prostate cancer,rs145204276,rs55829688

Data availability:

Keywords: PTEN, apoptosis, PDCD4, GAS5, prostate cancer, rs145204276, rs55829688

Mutations in GAS5 affect the transformation from benign prostate proliferation to aggressive prostate cancer by affecting the transcription efficiency of GAS5.

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Karger: Oncology

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