Adjuvant atezolizumab versus observation in muscle-invasive urothelial carcinoma (IMvigor010): a multicentre, open-label, randomised, phase 3 trial

Bellmunt, Joaquim; Hussain, Maha; Gschwend, Jurgen E.; Albers, Peter; Oudard, Stéphane; Castellano, Daniel; Daneshmand, Siamak; Nishiyama, Hiroyuki; Majchrowicz, Martin; Degaonkar, Viraj; Shi, Yi Feng; Mariathasan, Sanjeev; Grivas, Petros D; Drakaki, Alexandra; O'Donnell, Peter H; Rosenberg, Jonathan E; Geynisman, Daniel M; Petrylak, Daniel P; Hoffman-Censits, Jean; Bedke, Jens; Kalebasty, Arash Rezazadeh; Zakharia, Yousef; van der Heijden, Michiel S; Sternberg, Cora N; Davarpanah, Nicole N.; Powles, Thomas

doi:10.1016/S1470-2045(21)00004-8

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Adjuvant atezolizumab versus observation in muscle-invasive urothelial carcinoma (IMvigor010): a multicentre, open-label, randomised, phase 3 trial

Author(s): Joaquim Bellmunt , Maha Hussain , Jürgen E Gschwend , Peter Albers , Stephane Oudard , Daniel Castellano , Siamak Daneshmand , Hiroyuki Nishiyama , Martin Majchrowicz , Viraj Degaonkar , Yi Shi , Sanjeev Mariathasan , Petros Grivas , Alexandra Drakaki , Peter H O'Donnell , Jonathan E Rosenberg , Daniel M Geynisman , Daniel P Petrylak , Jean Hoffman-Censits , Jens Bedke , Arash Rezazadeh Kalebasty , Yousef Zakharia , Michiel S van der Heijden , Cora N Sternberg , Nicole N Davarpanah , Thomas Powles

Publication date Created: March 2021

Publication date (Print): March 2021

Journal: The Lancet Oncology

Publisher: Elsevier BV

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Pembrolizumab for Early Triple-Negative Breast Cancer

Peter J. Schmid, Javier Cortés, Lajos Pusztai … (2020)

Previous trials showed promising antitumor activity and an acceptable safety profile associated with pembrolizumab in patients with early triple-negative breast cancer. Whether the addition of pembrolizumab to neoadjuvant chemotherapy would significantly increase the percentage of patients with early triple-negative breast cancer who have a pathological complete response (defined as no invasive cancer in the breast and negative nodes) at definitive surgery is unclear.

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Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

Joaquim Bellmunt, Ronald de Wit, David J Vaughn … (2017)

New England Journal of Medicine, 376(11), 1015-1026

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Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.

Jonathan E Rosenberg, Jean Hoffman-Censits, Tom Powles … (2016)

Patients with metastatic urothelial carcinoma have few treatment options after failure of platinum-based chemotherapy. In this trial, we assessed treatment with atezolizumab, an engineered humanised immunoglobulin G1 monoclonal antibody that binds selectively to programmed death ligand 1 (PD-L1), in this patient population.

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Author and article information

Journal

Title: The Lancet Oncology

Abbreviated Title: The Lancet Oncology

Publisher: Elsevier BV

ISSN (Print): 14702045

Publication date Created: March 2021

Publication date (Print): March 2021

Article

DOI: 10.1016/S1470-2045(21)00004-8

PubMed ID: 33721560

SO-VID: ac186c6a-8646-4542-9434-85b113247102

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https://www.elsevier.com/tdm/userlicense/1.0/

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