Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial.

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Abstract

An abscopal response describes radiotherapy-induced immune-mediated tumour regression at sites distant to the irradiated field. Granulocyte-macrophage colony-stimulating factor is a potent stimulator of dendritic cell maturation. We postulated that the exploitation of the pro-immunogenic effects of radiotherapy with granulocyte-macrophage colony-stimulating factor might result in abscopal responses among patients with metastatic cancer.

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Journal

Journal ID (iso-abbrev): Lancet Oncol.

Title: The Lancet. Oncology

ISSN (Electronic): 1474-5488

ISSN (Print): 1470-2045

Publication date (Electronic): Jul 2015

Volume: 16

Issue: 7

Affiliations

[1 ] Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA.

[2 ] Department of Radiation Oncology, SUNY Downstate, New York, NY, USA.

[3 ] Department of Medicine, New York University School of Medicine, New York, NY, USA.

[4 ] Department of Radiology, New York University School of Medicine, New York, NY, USA.

[5 ] Division of Biostatistics, New York University School of Medicine, New York, NY, USA.

[6 ] Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA; Department of Pathology, New York University School of Medicine, New York, NY, USA.

[7 ] Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. Electronic address: formenti@med.cornell.edu.

Article

Publisher Item ID: S1470-2045(15)00054-6

DOI: 10.1016/S1470-2045(15)00054-6

PubMed ID: 26095785

SO-VID: ab1b9c3d-a8c0-4724-a6c5-dc053a5c5a13

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