12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Parkin is downregulated among autophagy-related proteins prior to hyperphosphorylation of Tau in TS65DN mice.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Autophagy is a pathway through which cells execute a plethora of functions, such as macromolecules and organelles quality control, recycling of building blocks and apoptosis. Numerous studies have shown in the past that autophagy is an important mechanism associated with the pathology of various neurodegenerative diseases, whose impairment may lead to several disease-characteristic phenotypes (e.g. misfolded protein and defective organelles accumulation). With this in mind, we aimed to investigate whether alterations in expression of autophagy-related proteins would show before hyperphosphorylation of Tau, a hallmark of Alzheimer's disease (AD). After analyzing 7 different proteins, we observed that, while Pink1 and p62 show an age-related reduction in the Ts65Dn mice respectively in the locus coeruleus and hippocampus, Parkin shows an age-genotype interaction-associated reduction in both brain areas. This suggests potential outcomes in pathways associated with Parkin that could relate to later stages of the disease development.

          Related collections

          Author and article information

          Journal
          Biochem Biophys Res Commun
          Biochemical and biophysical research communications
          Elsevier BV
          1090-2104
          0006-291X
          Jul 05 2021
          : 561
          Affiliations
          [1 ] Departamento de Genetica e Biologia Evolutiva, Instituto de Biociencias. Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: alan.henrique@usp.br.
          [2 ] Departamento de Genetica e Biologia Evolutiva, Instituto de Biociencias. Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
          Article
          S0006-291X(21)00787-7
          10.1016/j.bbrc.2021.05.016
          34015759
          aad0c640-9a13-4125-a6a5-b545ca5f701b
          History

          Autophagy,Neurodegeneration,Ageing,Parkin
          Autophagy, Neurodegeneration, Ageing, Parkin

          Comments

          Comment on this article