Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Abstract

In spite of the considerable achievements in the field of regenerative medicine in the past several decades, osteochondral defect regeneration remains a challenging issue among diseases in the musculoskeletal system because of the spatial complexity of osteochondral units in composition, structure and functions. In order to repair the hierarchical tissue involving different layers of articular cartilage, cartilage-bone interface and subchondral bone, traditional clinical treatments including palliative and reparative methods have showed certain improvement in pain relief and defect filling. It is the development of tissue engineering that has provided more promising results in regenerating neo-tissues with comparable compositional, structural and functional characteristics to the native osteochondral tissues. Here in this review, some basic knowledge of the osteochondral units including the anatomical structure and composition, the defect classification and clinical treatments will be first introduced. Then we will highlight the recent progress in osteochondral tissue engineering from perspectives of scaffold design, cell encapsulation and signaling factor incorporation including bioreactor application. Clinical products for osteochondral defect repair will be analyzed and summarized later. Moreover, we will discuss the current obstacles and future directions to regenerate the damaged osteochondral tissues.

Graphical abstract

Highlights

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  Building materials are summarized: polymers, bioceramics, metals and ECM-based ones.

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  The advancing gradient scaffolds include multiphasic and continuous gradient ones.

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  Signaling factors are sorted into biochemical, and physiochemical and physical ones.

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  The commercially available products are introduced and categorized into three types.

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  Four biggest challenges are proposed followed by some possible future directions.