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Analysis of two capreomycin-resistance determinants from Streptomyces capreolus and characterization of the action of their products
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Abstract
Two genes encoding capreomycin (Cp)-modifying enzymes have been isolated from the
producing organism Streptomyces capreolus. Cp acetyltransferase (CAC), encoded by
cac, is active against all four components of the Cp complex, whereas Cp phosphotransferase
(CPH), the product of cph, is active against Cp components IA and IIA (and also the
related antibiotic, Vm) but not against Cp IB or Cp IIB.