Development and experimental validation of an M2 macrophage and platelet‐associated gene signature to predict prognosis and immunotherapy sensitivity in bladder cancer

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Abstract

Platelets and M2 macrophages both play crucial roles in tumorigenesis, but their relationship and the prognosis value of the relative genes in bladder cancer (BLCA) remain obscure. In the present study, we found that platelets stimulated by BLCA cell lines could promote M2 macrophage polarization, and platelets were significantly associated with the infiltration of M2 macrophages in BLCA samples. Through the bioinformatic analyses, A2M, TGFB3, and MYLK, which were associated with platelets and M2 macrophages, were identified and verified in vitro and then included in the predictive model. A platelet and M2 macrophage‐related gene signature was constructed to evaluate the prognosis and immunotherapeutic sensitivity, helping to guide personalized treatment and to disclose the underlying mechanisms.

Abstract

Platelets stimulated by UMUC3 could promote M2 macrophage polarization, and platelets were significantly associated with the infiltration of M2 macrophages in bladder cancer samples. Through the bioinformatic analyses, A2M, TGFB3, and MYLK, which were associated with platelets and M2 macrophages, were identified and verified in vitro and then included in the predictive model. A platelet and M2 macrophage‐related gene signature was constructed to evaluate the prognosis and immunotherapeutic sensitivity, helping to guide personalized treatment and to disclose the underlying mechanisms.

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Cancer statistics, 2023

Rebecca L Siegel, Kimberly D Miller, Nikita Sandeep Wagle … (2023)

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries and mortality data collected by the National Center for Health Statistics. In 2023, 1,958,310 new cancer cases and 609,820 cancer deaths are projected to occur in the United States. Cancer incidence increased for prostate cancer by 3% annually from 2014 through 2019 after two decades of decline, translating to an additional 99,000 new cases; otherwise, however, incidence trends were more favorable in men compared to women. For example, lung cancer in women decreased at one half the pace of men (1.1% vs. 2.6% annually) from 2015 through 2019, and breast and uterine corpus cancers continued to increase, as did liver cancer and melanoma, both of which stabilized in men aged 50 years and older and declined in younger men. However, a 65% drop in cervical cancer incidence during 2012 through 2019 among women in their early 20s, the first cohort to receive the human papillomavirus vaccine, foreshadows steep reductions in the burden of human papillomavirus-associated cancers, the majority of which occur in women. Despite the pandemic, and in contrast with other leading causes of death, the cancer death rate continued to decline from 2019 to 2020 (by 1.5%), contributing to a 33% overall reduction since 1991 and an estimated 3.8 million deaths averted. This progress increasingly reflects advances in treatment, which are particularly evident in the rapid declines in mortality (approximately 2% annually during 2016 through 2020) for leukemia, melanoma, and kidney cancer, despite stable/increasing incidence, and accelerated declines for lung cancer. In summary, although cancer mortality rates continue to decline, future progress may be attenuated by rising incidence for breast, prostate, and uterine corpus cancers, which also happen to have the largest racial disparities in mortality.

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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao, Yang Liu, Jing Yuan … (2020)

Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.

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Immune Microenvironment in Glioblastoma Subtypes

Zhihong Chen, Dolores Hambardzumyan (2018)

Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to their malignant growth and invasion into the brain parenchyma coupled with resistance to therapy, GBMs are among the deadliest of all cancers. GBMs are highly heterogeneous at both the molecular and histological levels. Hallmark histological structures include pseudopalisading necrosis and microvascular proliferation. In addition to high levels of intratumoral heterogeneity, GBMs also exhibit high levels of inter-tumoral heterogeneity. The major non-neoplastic cell population in the GBM microenvironment includes cells of the innate immune system called tumor-associated macrophages (TAMs). Correlative data from the literature suggest that molecularly distinct GBM subtypes exhibit differences in their microenvironment. Data from mouse models of GBM suggest that genetic driver mutations can create unique microenvironments. Here, we review the origin, features, and functions of TAMs in distinct GBM subtypes. We also discuss their interactions with other immune cell constituents and discuss prospects of therapeutically targeting TAMs to increase the efficacy of T-cell functions.

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Author and article information

Contributors

Bahaerguli Muhuitijiang: bahar8h2@163.com

Xiaojun Shi: 13395638975@163.com

Wanlong Tan:

ORCID: https://orcid.org/0000-0003-4265-4494

13064923513@163.com

Journal

Journal ID (nlm-ta): Cancer Sci

Journal ID (iso-abbrev): Cancer Sci

Journal ID (doi): 10.1111/(ISSN)1349-7006

Journal ID (publisher-id): CAS

Title: Cancer Science

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 1347-9032

ISSN (Electronic): 1349-7006

Publication date (Electronic): 29 February 2024

Publication date Collection: May 2024

Volume: 115

Issue: 5 ( doiID: 10.1111/cas.v115.5 )

Pages: 1417-1432

Affiliations

[ ¹ ] Department of Urology, Nanfang Hospital Southern Medical University Guangzhou China

[ ² ] The First Clinical Medical College of Southern Medical University Guangzhou Guangdong China

Author notes

[*] [* ] Correspondence

Wanlong Tan and Xiaojun Shi, Department of Urology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong 510080, China.

Email: 13064923513@ 123456163.com ; 13395638975@ 123456163.com

Author information

Zhiyong Zhang https://orcid.org/0000-0003-4146-6184

Wanlong Tan https://orcid.org/0000-0003-4265-4494

Article

Publisher ID: CAS16113 Other ID: CAS-OA-1201-2023.R2

DOI: 10.1111/cas.16113

PMC ID: 11093213

PubMed ID: 38422408

SO-VID: aa551f43-db88-4da6-9737-ce5d3a893985

License:

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

History

Date revision received : 20 November 2023

Date received : 30 May 2023

Date accepted : 31 January 2024

Page count

Figures: 10, Tables: 0, Pages: 16, Words: 6659

Funding

Funded by: National Natural Science Foundation of China , doi 10.13039/501100001809;

Award ID: 82372867

Award ID: 82073162

Funded by: Guangzhou Municipal Science and Technology Project , doi 10.13039/501100010256;

Award ID: 202002030482

Custom metadata

source-schema-version-number 2.0

cover-date May 2024

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.4.2 mode:remove_FC converted:14.05.2024

ScienceOpen disciplines: Oncology & Radiotherapy

Keywords: bladder cancer,immunotherapy,m2 macrophage,platelet,prognosis

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ScienceOpen disciplines: Oncology & Radiotherapy

Keywords: bladder cancer, immunotherapy, m2 macrophage, platelet, prognosis

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Development and experimental validation of an M2 macrophage and platelet‐associated gene signature to predict prognosis and immunotherapy sensitivity in bladder cancer

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Cancer Immunotherapy

Most cited references 52

Cancer statistics, 2023

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Immune Microenvironment in Glioblastoma Subtypes

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