14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Automatic diagnosis of the 12-lead ECG using a deep neural network

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are great expectations on how it might improve clinical practice. Here we present a DNN model trained in a dataset with more than 2 million labeled exams analyzed by the Telehealth Network of Minas Gerais and collected under the scope of the CODE (Clinical Outcomes in Digital Electrocardiology) study. The DNN outperform cardiology resident medical doctors in recognizing 6 types of abnormalities in 12-lead ECG recordings, with F1 scores above 80% and specificity over 99%. These results indicate ECG analysis based on DNNs, previously studied in a single-lead setup, generalizes well to 12-lead exams, taking the technology closer to the standard clinical practice.

          Abstract

          The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. In that context, the authors present a Deep Neural Network (DNN) that recognizes different abnormalities in ECG recordings which matches or outperform cardiology and emergency resident medical doctors.

          Related collections

          Most cited references32

          • Record: found
          • Abstract: not found
          • Book Chapter: not found

          Identity Mappings in Deep Residual Networks

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network

            Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow1. Widely available digital ECG data and the algorithmic paradigm of deep learning2 present an opportunity to substantially improve the accuracy and scalability of automated ECG analysis. However, a comprehensive evaluation of an end-to-end deep learning approach for ECG analysis across a wide variety of diagnostic classes has not been previously reported. Here, we develop a deep neural network (DNN) to classify 12 rhythm classes using 91,232 single-lead ECGs from 53,549 patients who used a single-lead ambulatory ECG monitoring device. When validated against an independent test dataset annotated by a consensus committee of board-certified practicing cardiologists, the DNN achieved an average area under the receiver operating characteristic curve (ROC) of 0.97. The average F1 score, which is the harmonic mean of the positive predictive value and sensitivity, for the DNN (0.837) exceeded that of average cardiologists (0.780). With specificity fixed at the average specificity achieved by cardiologists, the sensitivity of the DNN exceeded the average cardiologist sensitivity for all rhythm classes. These findings demonstrate that an end-to-end deep learning approach can classify a broad range of distinct arrhythmias from single-lead ECGs with high diagnostic performance similar to that of cardiologists. If confirmed in clinical settings, this approach could reduce the rate of misdiagnosed computerized ECG interpretations and improve the efficiency of expert human ECG interpretation by accurately triaging or prioritizing the most urgent conditions.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Application of deep convolutional neural network for automated detection of myocardial infarction using ECG signals

                Bookmark

                Author and article information

                Contributors
                antonio-ribeiro@ufmg.br
                thomas.schon@it.uu.se
                antonio.ribeiro@ebserh.gov.br
                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Publishing Group UK (London )
                2041-1723
                9 April 2020
                9 April 2020
                2020
                : 11
                : 1760
                Affiliations
                [1 ]ISNI 0000 0001 2181 4888, GRID grid.8430.f, Universidade Federal de Minas Gerais, ; Belo Horizonte, Brazil
                [2 ]ISNI 0000 0004 1936 9457, GRID grid.8993.b, Uppsala University, ; Uppsala, Sweden
                [3 ]ISNI 0000 0004 0481 5100, GRID grid.500232.6, Telehealth Center from Hospital das Clínicas da Universidade Federal de Minas Gerais, ; Belo Horizonte, Brazil
                [4 ]ISNI 0000 0001 2193 314X, GRID grid.8756.c, University of Glasgow, ; Glasgow, Scotland
                Author information
                http://orcid.org/0000-0003-3632-8529
                http://orcid.org/0000-0001-5183-234X
                http://orcid.org/0000-0002-2740-0042
                Article
                15432
                10.1038/s41467-020-15432-4
                7145824
                32273514
                aa2f0b71-6d3c-47d6-9bd5-750d96cc506f
                © The Author(s) 2020

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 28 February 2019
                : 17 February 2020
                Funding
                Funded by: FundRef https://doi.org/10.13039/501100003593, Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development);
                Award ID: 465518/2014-1
                Award Recipient :
                Categories
                Article
                Custom metadata
                © The Author(s) 2020

                Uncategorized
                cardiology,electrodiagnosis,computational science
                Uncategorized
                cardiology, electrodiagnosis, computational science

                Comments

                Comment on this article