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      A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

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          Abstract

          Traditional Chinese medicine polysaccharides (TCMPs) are plentiful and renewable resources with properties such as biocompatibility, hydrophilicity, biodegradability, and low cytotoxicity. Because the polysaccharide molecular chain contains a variety of active groups, different polysaccharide derivatives can be easily produced through chemical modification. They have been increasingly used in drug delivery systems (DDS). However, the potential of polysaccharides is usually ignored due to their structural complexity, poor stability or ambiguity of mechanisms of actions. This review summarized the applications of TCMPs in DDS around four main aspects. The general characteristics of TCMPs as drug delivery carriers, as well as the relationships between structure and function of them were summarized. Meanwhile, the direction of preparing multifunctional drug delivery materials with synergistic effect by using TCMPs was discussed. This review aims to become a reference for further research of TCMPs and their derivatives, especially applications of them as carriers in pharmaceutical preparation industry.

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          Polysaccharides-based nanoparticles as drug delivery systems.

          Zonghua Liu, Yanpeng Jiao, Yifei Wang … (2008)
          Natural polysaccharides, due to their outstanding merits, have received more and more attention in the field of drug delivery systems. In particular, polysaccharides seem to be the most promising materials in the preparation of nanometeric carriers. This review relates to the newest developments in the preparation of polysaccharides-based nanoparticles. In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crosslinking, polyelectrolyte complex, and the self-assembly of hydrophobically modified polysaccharides.
          Article 0 comments Cited 336 times – based on 0 reviews     Review now
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            Bioactivity of phenolic acids: metabolites versus parent compounds: a review.

            Sandrina Heleno, Anabela Martins, Maria João R. P. Queiroz … (2015)
            Phenolic acids are present in our diet in different foods, for example mushrooms. Due to their bioactive properties, phenolic acids are extensively studied and there is evidence of their role in disease prevention. Nevertheless, in vivo, these compounds are metabolized and circulate in the organism as glucuronated, sulphated and methylated metabolites, displaying higher or lower bioactivities. To clarify the importance of the metabolism of phenolic acids, knowledge about the bioactivity of metabolites is extremely important. In this review, chemical features, biosynthesis and bioavailability of phenolic acids are discussed, as well as the chemical and enzymatic synthesis of their metabolites. Finally, metabolite bioactive properties are compared with that of the corresponding parental compounds.
            Article 0 comments Cited 205 times – based on 0 reviews     Review now
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              Current advances in the fabrication of microneedles for transdermal delivery.

              Sunaina Indermun, Regina Luttge, Yahya E. Choonara … (2014)
              The transdermal route is an excellent site for drug delivery due to the avoidance of gastric degradation and hepatic metabolism, in addition to easy accessibility. Although offering numerous attractive advantages, many available transdermal systems are not able to deliver drugs and other compounds as desired. The use of hypodermic needles, associated with phobia, pain and accidental needle-sticks has been used to overcome the delivery limitation of macromolecular compounds. The means to overcome the disadvantages of hypodermic needles has led to the development of microneedles for transdermal delivery. However, since the initial stages of microneedle fabrication, recent research has been conducted integrating various fabrication techniques for generating sophisticated microneedle devices for transdermal delivery including progress on their commercialization. A concerted effort has been made within this review to highlight the current advances of microneedles, and to provide an update of pharmaceutical research in the field of microneedle-assisted transdermal drug delivery systems.
              Article 0 comments Cited 96 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Xiaobin Jia: jiaxiaobin2015@163.com
                Liang Feng: wenmoxiushi@163.com
                Journal
                Journal ID (nlm-ta): Chin Med
                Journal ID (iso-abbrev): Chin Med
                Title: Chinese Medicine
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1749-8546
                Publication date (Electronic): 15 January 2022
                Publication date PMC-release: 15 January 2022
                Publication date Collection: 2022
                Volume: 17
                Electronic Location Identifier: 12
                Affiliations
                GRID grid.254147.1, ISNI 0000 0000 9776 7793, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, , China Pharmaceutical University, ; Nanjing, 211198 People’s Republic of China
                Article
                Publisher ID: 567
                DOI: 10.1186/s13020-021-00567-3
                PMC ID: 8760834
                PubMed ID: 35033122
                SO-VID: a9a07dbf-acf8-4c22-a2ac-c65198cb7bbd
                Copyright © © The Author(s) 2022
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 14 October 2021
                Date accepted : 30 December 2021
                Funding
                Funded by: National Key research and development program of China
                Award ID: 2018YFC1706906
                Award Recipient :
                Funded by: “Double First-Class” University project of China Pharmaceutical University
                Award ID: CPU2018GF07
                Award ID: CPU2018PZQ19
                Award Recipient :
                Funded by: National Natural Science Foundation Committee of P.R. China
                Award ID: 81973536
                Award Recipient :
                Funded by: Special Fund for Transformation of Scientific and Technological Achievements in Jiangsu Province
                Award ID: BA2020077
                Award Recipient :
                Funded by: Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University
                Award ID: SKLNMZZ202025
                Award Recipient :
                Categories
                Subject: Review
                Custom metadata
                issue-copyright-statement © The Author(s) 2022

                ScienceOpen disciplines: Complementary & Alternative medicine
                Keywords: polysaccharide,traditional chinese medicine,drug delivery systems,synergistic effect
                Data availability:
                ScienceOpen disciplines: Complementary & Alternative medicine
                Keywords: polysaccharide, traditional chinese medicine, drug delivery systems, synergistic effect

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