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      Selective label-free detection of G-quadruplex structure of human telomere by emission spectral changes in visible-and-NIR region under physiological condition through the FRET of a two-component PPE-SO3−–Pt(ii) complex ensemble with Pt⋯Pt, electrostatic and π–π interactions

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      Chem. Sci.
      Royal Society of Chemistry (RSC)

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          Chemical sensors based on amplifying fluorescent conjugated polymers.

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            Near-infrared optical sensors based on single-walled carbon nanotubes.

            Molecular detection using near-infrared light between 0.9 and 1.3 eV has important biomedical applications because of greater tissue penetration and reduced auto-fluorescent background in thick tissue or whole-blood media. Carbon nanotubes have a tunable near-infrared emission that responds to changes in the local dielectric function but remains stable to permanent photobleaching. In this work, we report the synthesis and successful testing of solution-phase, near-infrared sensors, with beta-D-glucose sensing as a model system, using single-walled carbon nanotubes that modulate their emission in response to the adsorption of specific biomolecules. New types of non-covalent functionalization using electron-withdrawing molecules are shown to provide sites for transferring electrons in and out of the nanotube. We also show two distinct mechanisms of signal transduction-fluorescence quenching and charge transfer. The results demonstrate new opportunities for nanoparticle optical sensors that operate in strongly absorbing media of relevance to medicine or biology.
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              Telomere maintenance as a target for anticancer drug discovery.

              Maintenance of telomeres--specialized complexes that protect the ends of chromosomes--is undertaken by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells that have been examined so far, but is absent in most normal cells. So, targeting telomere-maintenance mechanisms could potentially half tumour growth across a broad spectrum of tumour types, with little cytotoxic effect outside tumours. Here, we describe the current understanding of telomere biology, and the application of this knowledge to the development of anticancer drugs.
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                Author and article information

                Journal
                CSHCBM
                Chem. Sci.
                Chem. Sci.
                Royal Society of Chemistry (RSC)
                2041-6520
                2041-6539
                2013
                2013
                : 4
                : 1
                : 377-387
                Article
                10.1039/C2SC20897K
                a910adf4-b0a2-4ef7-bbbe-db0cd620f8ae
                © 2013
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