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Abstract
The signaling adaptor p62 is a multidomain protein implicated in the activation of
the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic
apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by
autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision
points that control cell death and survival.