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      Activation energy with exothermic/endothermic reaction and Coriolis force effects on magnetized nanomaterials flow through Darcy–Forchheimer porous space with variable features

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      Waves in Random and Complex Media
      Informa UK Limited

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          Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

          Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide.
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            Natural convection boundary layer with suction and mass transfer in a porous medium

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              Enhancement of thermal conductivity with Cu for nanofluids using chemical reduction method

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                Author and article information

                Journal
                Waves in Random and Complex Media
                Waves in Random and Complex Media
                Informa UK Limited
                1745-5030
                1745-5049
                January 19 2022
                : 1-14
                Affiliations
                [1 ]Department of Sciences and Humanities, National University of Computer and Emerging Sciences, Peshawar, Pakistan
                Article
                10.1080/17455030.2021.2023779
                a8ac7dda-13f1-498d-971d-0c9b949ba3fb
                © 2022
                History

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