Analysis of PTPN22 C1858T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran.

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Abstract

Type 1 diabetes (T1D) is a T-cell mediated autoimmune multifactorial disease. The PTPN22 gene encodes an intracellular lymphoid-specific phosphatase (Lyp) that has been shown to play a negative regulatory role in T cell activation.

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Author and article information

Journal

Journal ID (iso-abbrev): Cell. Immunol.

Title: Cellular immunology

Publisher: Elsevier BV

ISSN (Electronic): 1090-2163

ISSN (Print): 0008-8749

Publication date (Electronic): September 23 2014

Volume: 292

Issue: 1-2

Affiliations

[1 ] Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: almasysh@sums.ac.ir.

[2 ] Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: aliparasty@sums.ac.ir.

[3 ] Departments of Immunology and Medicine, Sunnybrook and Women's College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada.

[4 ] Bone Research Center, Endocrine Section, Department of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

[5 ] Department of Virology, School of Medicine, University of Tampere, Tampere, Finland.

[6 ] Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Article

Publisher Item ID: S0008-8749(14)00132-4

DOI: 10.1016/j.cellimm.2014.08.007

PubMed ID: 25243643

SO-VID: a88bb7f8-7ff3-4bfa-ad75-1d48125ebb87

History

Keywords: PTPN22,Gene polymorphism,Hashimoto’s thyroiditis,Type 1 diabetes

Data availability:

Keywords: PTPN22, Gene polymorphism, Hashimoto’s thyroiditis, Type 1 diabetes

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