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      The Citius End: World Records Progression Announces the Completion of a Brief Ultra-Physiological Quest

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          World records (WR) in sports illustrate the ultimate expression of human integrated muscle biology, through speed or strength performances. Analysis and prediction of man's physiological boundaries in sports and impact of external (historical or environmental) conditions on WR occurrence are subject to scientific controversy. Based on the analysis of 3263 WR established for all quantifiable official contests since the first Olympic Games, we show here that WR progression rate follows a piecewise exponential decaying pattern with very high accuracy (mean adjusted r 2 values = 0.91±0.08 (s.d.)). Starting at 75% of their estimated asymptotic values in 1896, WR have now reached 99%, and, present conditions prevailing, half of all WR will not be improved by more than 0,05% in 2027. Our model, which may be used to compare future athletic performances or assess the impact of international antidoping policies, forecasts that human species' physiological frontiers will be reached in one generation. This will have an impact on the future conditions of athlete training and on the organization of competitions. It may also alter the Olympic motto and spirit.

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          Most cited references29

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          Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans.

          More than a billion humans worldwide are predicted to be completely deficient in the fast skeletal muscle fiber protein alpha-actinin-3 owing to homozygosity for a premature stop codon polymorphism, R577X, in the ACTN3 gene. The R577X polymorphism is associated with elite athlete status and human muscle performance, suggesting that alpha-actinin-3 deficiency influences the function of fast muscle fibers. Here we show that loss of alpha-actinin-3 expression in a knockout mouse model results in a shift in muscle metabolism toward the more efficient aerobic pathway and an increase in intrinsic endurance performance. In addition, we demonstrate that the genomic region surrounding the 577X null allele shows low levels of genetic variation and recombination in individuals of European and East Asian descent, consistent with strong, recent positive selection. We propose that the 577X allele has been positively selected in some human populations owing to its effect on skeletal muscle metabolism.
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            The fall and rise of the gender difference in elite anaerobic performance 1952-2006.

            To compare the historical evolution of performance for males and females in anaerobically dominated sprint events in three different sports: running, swimming, and speed skating. Times of the top six finishers in a total of 283 men's and women's Olympic and world championship finals held between 1952 and 2006 were analyzed, and performance differences between males and females were calculated for each final position. After a relatively faster rate of improvement among females from the 1950s to a nadir in the 1980s, the gender difference in anaerobic performance at the highest levels of international competition has actually increased during the last 15 yr. Overall, the time-based performance difference for all six events analyzed has increased from a low of 10.3% in the period 1976-1988 to a current difference of 11.5% for the period 2000-2005. Analysis of elite sprinting performance in running, swimming, and speed skating during the last 50 yr reveals that the performance difference between males and females has ceased to narrow and has actually widened since the mid-1990s. The change observed cannot be explained by declining women's participation in sport, poorer training practice, or reduced access to technological developments, but it does coincide with dramatic improvements in the scope and sensitivity of drug testing. Current gender differences in performance, and the underlying differences in performance power, may now reasonably reflect the true physiological differences between males and females.
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              Will women soon outrun men?

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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2008
                6 February 2008
                : 3
                : 2
                : e1552
                Affiliations
                [1 ]Institute for Biomedical Research and Sports Epidemiology (IRMES), Paris, France
                [2 ]INSERM, IFR69, U780, Villejuif, France
                [3 ]Université Paris-Descartes, Paris, France
                [4 ]Centre National de la Recherche Scientifique (CNRS) UMR 8147, Hôpital Necker, Paris, France
                [5 ]Centre d'Investigation en Médecine du Sport (CIMS), Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
                Universidad Europea de Madrid, Spain
                Author notes
                * To whom correspondence should be addressed. E-mail: irmes@ 123456insep.fr

                Conceived and designed the experiments: OH GB JT XJ. Performed the experiments: GB JT VT NE. Analyzed the data: GB VT MT SE. Contributed reagents/materials/analysis tools: GB MT SE. Wrote the paper: GB JT.

                Article
                07-PONE-RA-02741R1
                10.1371/journal.pone.0001552
                2212132
                18253499
                a8736a9e-0ae1-4825-bfe0-d5bfd51baafe
                Berthelot et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
                History
                : 13 November 2007
                : 4 January 2008
                Page count
                Pages: 5
                Categories
                Research Article
                Evolutionary Biology
                Physiology
                Computer Science/Numerical Analysis and Theoretical Computing
                Mathematics/Algorithms
                Public Health and Epidemiology/Exercise and Sports
                Evolutionary Biology/Human Evolution

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