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Abstract
Pancreatic cancer usually results in poor survival with limited options for treatment,
as most affected individuals present with advanced disease. Early detection of preinvasive
pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities
for extending survival. Although screening for pancreatic cancer is currently not
recommended for the general population, emerging evidence indicates that pancreatic
surveillance can improve outcomes for individuals in certain high-risk groups. Changes
in the epidemiology of pancreatic cancer, experience from pancreatic surveillance,
and discovery of novel biomarkers provide a roadmap for new strategies for pancreatic
cancer risk assessment, early detection, and prevention.