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      Functional constituents of plant-based foods boost immunity against acute and chronic disorders

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          Abstract

          Plant-based foods are becoming an increasingly frequent topic of discussion, both scientific and social, due to the dissemination of information and exchange of experiences in the media. Plant-based diets are considered beneficial for human health due to the supply of many valuable nutrients, including health-promoting compounds. Replacing meat-based foods with plant-based products will provide many valuable compounds, including antioxidants, phenolic compounds, fibers, vitamins, minerals, and some ω3 fatty acids. Due to their high nutritional and functional composition, plant-based foods are beneficial in acute and chronic diseases. This article attempts to review the literature to present the most important data on nutrients of plant-based foods that can then help in the prevention of many diseases, such as different infections, such as coronavirus disease, pneumonia, common cold and flu, asthma, and bacterial diseases, such as bronchitis. A properly structured plant-based diet not only provides the necessary nutrients but also can help in the prevention of many diseases.

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          Plant polyphenols as dietary antioxidants in human health and disease

          Polyphenols are secondary metabolites of plants and are generally involved in defense against ultraviolet radiation or aggression by pathogens. In the last decade, there has been much interest in the potential health benefits of dietary plant polyphenols as antioxidant. Epidemiological studies and associated meta-analyses strongly suggest that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases. Here we present knowledge about the biological effects of plant polyphenols in the context of relevance to human health.
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            Vitamin C and Immune Function

            Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene regulating effects. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. In turn, infections significantly impact on vitamin C levels due to enhanced inflammation and metabolic requirements. Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections. Prophylactic prevention of infection requires dietary vitamin C intakes that provide at least adequate, if not saturating plasma levels (i.e., 100–200 mg/day), which optimize cell and tissue levels. In contrast, treatment of established infections requires significantly higher (gram) doses of the vitamin to compensate for the increased inflammatory response and metabolic demand.
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              Materials design for bone-tissue engineering

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                Author and article information

                Contributors
                Journal
                Open Life Sci
                Open Life Sci
                biol
                Open Life Sciences
                De Gruyter
                2391-5412
                08 September 2022
                2022
                : 17
                : 1
                : 1075-1093
                Affiliations
                Department of Food Science, Government College University , Faisalabad, 38000, Pakistan
                Institute of Food Science and Nutrition, University of Sargodha , Sargodha, 40100, Pakistan
                Department of Food Technology of Plant Origin, Poznań University of Life Sciences , 60-624 Poznań, Poland
                Department of Biotechnology, Persian Gulf Research Institute, Persian Gulf University , Bushehr, 75169, Iran
                Article
                biol-2022-0104
                10.1515/biol-2022-0104
                9462539
                36133422
                a7c8d8b9-37b5-43e8-9d0c-6c08f1e532e1
                © 2022 Waseem Khalid et al., published by De Gruyter

                This work is licensed under the Creative Commons Attribution 4.0 International License.

                History
                : 16 May 2022
                : 24 July 2022
                : 28 July 2022
                Page count
                Pages: 19
                Categories
                Review Article

                acute diseases,antioxidants,chronic diseases,immunity booster,nutraceuticals,phenolic compounds,minerals,vitamins

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