Exposure assessment to ochratoxin A through the intake of three cereal derivatives from the Moroccan market.

Abstract

Previous studies reported the contamination of cereals products with OTA in Morocco. Given bread, pasta and semolina are staple consumed food in the country, this study aims to assess the OTA exposure levels for the adult consumers in the country through cereal derivatives intake, by using a deterministic model based on the crossover of consumption and contamination data of 457 cereals products samples. The study also set out to determine under what conditions the OTA contributions from these 3 cereal derivatives alone were enough to cause a real public health problem in the country. The Estimated Weekly Intake EWI (ng/kg b.w./week) was used as an indicator of exposure for each cereal derivative. The global exposure (Total EWI) was determined by the summation of the EWI obtained for each cereal derivative for different consumers groups and at different OTA levels and nine scenarios were elaborated. Results showed that the total average OTA intake from the three cereal derivatives was estimated at 13.5 ng/kg b.w./week. Despite its low contamination levels, bread has been shown to be the main vector of exposure to OTA because of the high consumption levels by Moroccan adults. Its contribution to the total OTA intake was between 81 and 84% depending on the scenario. The contribution of the other investigated cereal products to total OTA intake seems to be modest and does not exceed 10% and 7% for semolina and pasta, respectively. The predominance of cereal derivatives in Moroccan food thus constitutes a potential risk factor for OTA exposure. Indeed, the risk of occurrence of potential adverse effects of OTA is real in three scenarios discussed in the study since the PTWI established by JECFA (100 ng/kg b.w./week) was exceeded. Moreover, the Maximum limit (3 ng/g) set by Moroccan regulations in 2016, seems to be less protective for the Moroccan consumers compared to other countries due to the high consumption level of cereal products. This situation is likely to cause a public health problem by the occurrence of specific pathologies at highly OTA exposed adults, especially high bread consumers.