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      Comparison of Micronutrient Intervention Strategies in Ghana and Benin to Cover Micronutrient Needs: Simulation of Bene-Fits and Risks in Women of Reproductive Age

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          Abstract

          Overlapping micronutrient interventions might increase the risk of excessive micronutrient intake, with potentially adverse health effects. To evaluate how strategies currently implemented in Benin and Ghana contribute to micronutrient intake in women of reproductive age (WRA), and to assess the risk for excess intakes, scenarios of basic rural and urban diets were built, and different on-going interventions were added. We estimated micronutrient intakes for all different scenarios. Four types of intervention were included in the scenarios: fortification, biofortification, supplementation and use of locally available nutrient-rich foods. Basic diets contributed poorly to daily micronutrient intake in WRA. Fortification of oil and salt were essential to reach daily requirements for vitamin A and iodine, while fortified flour contributed less. Biofortified products could make an important contribution to the coverage of vitamin A needs, while they were not sufficient to cover the needs of WRA. Iron and folic acid supplementation was a major contributor in the intake of iron and folate, but only in pregnant and lactating women. Risk of excess were found for three micronutrients (vitamin A, folic acid and niacin) in specific contexts, with excess only coming from voluntary fortified food, supplementation and the simultaneous overlap of several interventions. Better regulation and control of fortification and targeting of supplementation could avoid excess intakes.

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          Most cited references51

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          Developing country consumers’ acceptance of biofortified foods: a synthesis

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            Association of pulmonary tuberculosis with increased dietary iron.

            To determine whether increased dietary iron could be a risk factor for active tuberculosis, dietary iron history and human immunodeficiency virus (HIV) status were studied in 98 patients with pulmonary tuberculosis and in 98 control subjects from rural Zimbabwe. Exposure to high levels of dietary iron in the form of traditional beer is associated with increased iron stores in rural Africans. HIV seropositivity was associated with a 17.3-fold increase in the estimated odds of developing active tuberculosis (95% confidence interval [95% CI], 7.4-40.6; P<.001), and increased dietary iron was associated with a 3.5-fold increase (95% CI, 1.4-8.9; P=.009). Among patients treated for tuberculosis, HIV seropositivity was associated with a 3.8-fold increase in the estimated hazard ratio of death (95% CI, 1.0-13.8; P=.046), and increased dietary iron was associated with a 1.3-fold increase (95% CI, 0.4-6.4; P=.2). These findings are consistent with the hypothesis that elevated dietary iron may increase the risk of active pulmonary tuberculosis.
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              Provitamin A metabolism and functions in mammalian biology.

              J Lintig (2012)
              Vitamin A deficiency is a major public health problem in developing countries. Some studies also implicate a suboptimal vitamin A intake in certain parts of the population of the industrialized world. Provitamin A carotenoids such as β-carotene are the major source for retinoids (vitamin A and its derivatives) in the human diet. However, it is still controversial how much β-carotene intake is required and safe. An important contributor to this uncertainty is the lack of knowledge about the biochemical and molecular basis of β-carotene metabolism. Recently, key players of provitamin A metabolism have been molecularly identified and biochemically characterized. Studies in knockout mouse models showed that intestinal β-carotene absorption and conversion to retinoids is under negative feedback regulation that adapts this process to the actual requirement of vitamin A of the body. These studies also showed that in peripheral tissues a conversion of β-carotene occurs and affects retinoid-dependent physiologic processes. Moreover, these analyses provided a possible explanation for the adverse health effects of carotenoids by showing that a pathologic accumulation of these compounds can induce oxidative stress in mitochondria and cell signaling pathways related to disease. Genetic polymorphisms in identified genes exist in humans and also alter carotenoid homeostasis. Here, the advanced knowledge of β-carotene metabolism is reviewed, which provides a molecular framework for understanding the role of this important micronutrient in health and disease.
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Nutrients
                Nutrients
                nutrients
                Nutrients
                MDPI
                2072-6643
                01 July 2021
                July 2021
                : 13
                : 7
                : 2286
                Affiliations
                [1 ]Institut de Recherche pour le Développement (IRD), BP 64501-911, av. d’Agropolis, 34394 Montpellier, France; dassmamta20@ 123456gmail.com (M.D.); jacques.berger@ 123456ird.fr (J.B.); franck.wieringa@ 123456ird.fr (F.W.)
                [2 ]QualiSud, Univ Montpellier, Avignon Université, CIRAD, Institut Agro, IRD, Université de La Réunion, 34394 Montpellier, France
                [3 ]Nutrition Unit, Food Research Institute, Council for Scientific and Industrial Research (CSIR), Accra P.O. Box M20, Ghana; jolenenyako@ 123456yahoo.co.uk (J.N.); ctortoe@ 123456yahoo.co.uk (C.T.)
                [4 ]Faculté des Sciences Agronomiques (FSA), Université d’Abomey-Calavi (UAC), Jéricho 03 BP 2819, Benin; nadia@ 123456fogny.bj (N.F.-F.); eun_nago@ 123456yahoo.fr (E.N.); joseph.hounhouigan@ 123456gmail.com (J.H.)
                Author notes
                Author information
                https://orcid.org/0000-0002-2896-9310
                https://orcid.org/0000-0002-6010-355X
                https://orcid.org/0000-0001-7848-1885
                Article
                nutrients-13-02286
                10.3390/nu13072286
                8308306
                34371796
                a73b05b0-1baf-4dd2-972f-b2066e8493c1
                © 2021 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                : 25 May 2021
                : 28 June 2021
                Categories
                Article

                Nutrition & Dietetics
                micronutrients,fortification,supplementation,biofortification
                Nutrition & Dietetics
                micronutrients, fortification, supplementation, biofortification

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