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CCR5Δ32 – A piece of protection in the inflammatory puzzle of multiple sclerosis susceptibility
Lian Lopes Troncoso ,
Alessandra Pontillo ,
Enedina Maria Lobato de Oliveira ,
Alessandro Finkelszteijn ,
Silvete Schneider ,
José Artur Bogo Chies
August 2018
August 2018
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Abstract
Leucocyte infiltration and activation in the central nervous system (CNS) is an important
step in the pathogenesis of multiple sclerosis (MS). The Chemokine receptor 5 (CCR5)
is implicated in immune cell migration and cytokine release in the CNS, and it was
demonstrated to strongly contribute to CNS inflammation and damage in several models
of sterile and pathogen-mediated CNS diseases. Although the inhibition of CCR5 results
in a beneficial effect in experimental models of MS, conflicting results have been
found about the loss-of-function variant CCR5Δ32 (rs333) in MS patients. The aim of
this study was to evaluate the association of CCR5Δ32 and MS in a Brazilian case/control
cohort.