Contributors
Francesco Silvio Pasqualini: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Ashutosh Agarwal: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Blakely Bussie O'Connor: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Qihan Liu: Role: Formal analysisRole: MethodologyRole: Writing – review & editing
Sean P. Sheehy: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Kevin Kit Parker:
ORCID: http://orcid.org/0000-0002-5968-7535
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: Project administrationRole:
SupervisionRole: ValidationRole: Writing – original draftRole: Writing – review &
editing
Nic D. Leipzig: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
28
March
2018
Publication date Collection: 2018
Volume: 13
Issue: 3
Electronic Location Identifier: e0194706
Affiliations
[1
]
Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard
University, Cambridge, MA, United States of America
[2
]
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge,
MA, United States of America
[3
]
Department of Biomedical Engineering, University of Miami, Miami, FL, United States
of America
[4
]
Department of Pathology, University of Miami Miller School of Medicine, Miami, FL,
United States of America
[5
]
Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute, Miami, FL, United
States of America
The University of Akron, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-17-31941
DOI: 10.1371/journal.pone.0194706
PMC ID: 5874032
PubMed ID: 29590169
SO-VID: a696cf82-e998-474a-888f-ed58e47f5ab1
Copyright © © 2018 Pasqualini et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 30
August
2017
Date
accepted
: 8
March
2018
Page count
Figures: 4,
Tables: 0,
Pages: 14
Funding
Funded by: National Center for Advancing Translational Sciences (US)
Award ID: UH2 and UH3 awards TR000522 “Human Cardiopulmonary System On-a-Chip”
Award Recipient
:
ORCID: http://orcid.org/0000-0002-5968-7535
Kevin Kit Parker
Funded by: funder-id http://dx.doi.org/10.13039/100000185, Defense Advanced Research Projects Agency;
Award ID: BAA-11-73 “Human Microphysiological Systems Program”
Award Recipient
:
ORCID: http://orcid.org/0000-0002-5968-7535
Kevin Kit Parker
Funded by: funder-id http://dx.doi.org/10.13039/100000001, National Science Foundation;
Award ID: Materials Research Science and Engineering Center (MRSEC) grant DMR-1420570
Funded by: funder-id http://dx.doi.org/10.13039/100000001, National Science Foundation;
Award ID: ECS-0335765
The authors also acknowledge support from NIH NCATS UH2 and UH3 awards TR000522 “Human
Cardiopulmonary System On-a-Chip” to KKP, DARPA BAA-11-73 “Human Microphysiological
Systems Program” to KKP, and NSF Materials Research Science and Engineering Center
(MRSEC) grant DMR-1420570. This work was partially performed at the Harvard University
Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Infrastructure
Network (NNIN), which is supported by NSF award ECS-0335765. The funders had no role
in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Material Properties
Subject:
Mechanical Properties
Subject:
Stiffness
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Materials by Structure
Subject:
Amorphous Solids
Subject:
Gels
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Materials by Structure
Subject:
Mixtures
Subject:
Gels
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Muscle Physiology
Subject:
Muscle Contraction
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Muscle Physiology
Subject:
Muscle Contraction
Subject:
Science Policy
Subject:
Science and Technology Workforce
Subject:
Careers in Research
Subject:
Engineers
Subject:
People and Places
Subject:
Population Groupings
Subject:
Professions
Subject:
Engineers
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Muscle Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Muscle Tissue
Subject:
Muscle Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Muscle Tissue
Subject:
Muscle Cells
Subject:
Biology and Life Sciences
Subject:
Biotechnology
Subject:
Bioengineering
Subject:
Tissue Engineering
Subject:
Engineering and Technology
Subject:
Bioengineering
Subject:
Tissue Engineering
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Muscle Cells
Subject:
Myofibrils
Subject:
Sarcomeres
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Muscle Tissue
Subject:
Muscle Cells
Subject:
Myofibrils
Subject:
Sarcomeres
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Muscle Tissue
Subject:
Muscle Cells
Subject:
Myofibrils
Subject:
Sarcomeres
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Physiology
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