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      MEN and SIN: what's the difference?

      Author(s): ,
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      Journal: Nature Reviews Molecular Cell Biology
      Publisher: Springer Science and Business Media LLC

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A conserved signalling cascade--termed the mitotic-exit network in budding yeast and the septation-initiation network in fission yeast--controls key events during exit from mitosis and cytokinesis. Although the components of these signalling networks are highly conserved between the two yeasts, the outputs seem quite different. How, then, do these two pathways function, and how are they regulated?

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          Cyclin-dependent kinases: engines, clocks, and microprocessors.

          D Morgan (1997)
          Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.
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            Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.

            T Xu, W. Wang, S. Zhang … (1995)
            We have identified recessive overproliferation mutations by screening and examining clones of mutant cells in genetic mosaics of the fruitfly Drosophila melanogaster. This type of screen provides a powerful approach for identifying and studying potential tumor suppressors. One of the identified genes, lats, has been cloned and encodes a putative protein kinase that shares high levels of sequence similarity with three proteins in budding yeast and Neurospora that are involved in regulation of the cell cycle and growth. Mutations in lats cause dramatic overproliferation phenotypes and various developmental defects in both mosaic animals and homozygous mutants.
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              S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.

              M.Andrew Hoyt, Laura Totis, B.Tibor Roberts (1991)
              We have identified mutant strains of S. cerevisiae that fail to properly arrest their cell cycles at mitosis in response to the loss of microtubule function. New bud emergence and DNA replication (but not cytokinesis) occur with high efficiency in the mutants under conditions that inhibit these events in wild-type cells. The inability to halt cell cycle progression is specific for impaired microtubule function; the mutants respond normally to other cell cycle-blocking treatments. Under microtubule-disrupting conditions, the mutants neither achieve nor maintain the high level of histone H1 kinase activity characteristic of wild-type cells. Our studies have defined three genes required for normal cell cycle arrest. These findings are consistent with the existence of a surveillance system that halts the cell cycle in response to microtubule perturbation.
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                Author and article information

                Journal
                Title: Nature Reviews Molecular Cell Biology
                Abbreviated Title: Nat Rev Mol Cell Biol
                Publisher: Springer Science and Business Media LLC
                ISSN (Print): 1471-0072
                ISSN (Electronic): 1471-0080
                Publication date Created: November 2001
                Publication date (Print): November 2001
                Volume: 2
                Issue: 11
                Pages: 815-826
                Article
                DOI: 10.1038/35099020
                PubMed ID: 11715048
                SO-VID: a5c2d99f-a764-4f32-b3d7-2313312c164b
                Copyright © © 2001
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                http://www.springer.com/tdm

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