Sex and death: what is the connection?

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

A cost of reproduction, where lifespan and fecundity are negatively correlated, is of widespread occurrence. Mutations in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model organisms but do not always reduce fecundity, suggesting that the link between lifespan and fecundity is not inevitable. Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Cell

Title: Cell

Publisher: Elsevier BV

ISSN: 0092-8674

ISSN (Print): 0092-8674

Publication date (Electronic): Feb 25 2005

Volume: 120

Issue: 4

Affiliations

[1 ] UCL Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom. l.partridge@ucl.ac.uk

Article

Publisher Item ID: S0092-8674(05)00100-5

DOI: 10.1016/j.cell.2005.01.026

PubMed ID: 15734679

SO-VID: a567f619-4c68-49de-8b05-6449d000e901

History

Data availability:

Comments

Comment on this article

scite_

0

Smart Citations

0

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.