There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Parkinson's disease, Alzheimer's disease and other neurodegenerative disorders share
a common pathologic pathway with aggregation and deposition of misfolded proteins
causing a disruption of particular neuronal networks. Several mechanisms have been
implicated in the down-stream events following deposition of misfolded proteins including
failure of cellular defenses among many others. Recently, naturally occurring autoantibodies
against ss-amyloid and alpha-synuclein have been detected in healthy persons and altered
levels in patients were associated with particular neurodegenerative disorders. In
this review the current knowledge on the role of naturally occurring autoantibodies
is discussed in respect to neurodegenerative disorders.