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      Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome.

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          Abstract

          We investigated suspected food intolerances in patients with irritable bowel syndrome (IBS) using confocal laser endomicroscopy (CLE) for real-time visualization of structural/functional changes in the intestinal mucosa after food challenge. Patients with functional changes after food challenge (CLE+) were placed on personalized exclusion diets and followed up for long-term symptom relief.

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          Author and article information

          Journal
          Gastroenterology
          Gastroenterology
          1528-0012
          0016-5085
          Nov 2014
          : 147
          : 5
          Affiliations
          [1 ] Unit of Experimental Endoscopy, Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address: fri.rav@btopenworld.com.
          [2 ] Institute of Translational Immunology, Department of Medicine I, University of Mainz, Mainz, Germany; Research Center for Immunology, University of Mainz, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
          [3 ] Unit of Experimental Endoscopy, Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
          [4 ] Department of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany.
          [5 ] Department of Dermatology, University Hospital Schleswig-Holstein, Kiel, Germany.
          [6 ] Department of Anatomy, Christian Albrecht University, Kiel, Germany.
          [7 ] University College London Institute of Child Health, University College London, London, United Kingdom.
          Article
          S0016-5085(14)00971-8
          10.1053/j.gastro.2014.07.046
          25083606
          a47961da-aba3-42df-8521-a30cf65f4568
          Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.
          History

          FODMAP,Food Allergy,Gluten,Imaging
          FODMAP, Food Allergy, Gluten, Imaging

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