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      Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of ‘high definition’ neuroimaging

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      Current Opinion in Neurobiology
      Elsevier BV

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          Abstract

          <p class="first" id="d5455481e71">The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future 'high definition' clinical datasets. </p>

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          Author and article information

          Journal
          Current Opinion in Neurobiology
          Current Opinion in Neurobiology
          Elsevier BV
          09594388
          February 2015
          February 2015
          : 30
          : 1-8
          Article
          10.1016/j.conb.2014.08.005
          4293331
          25212469
          a3c629ed-1008-4d91-aa6b-fa08e06c9a9f
          © 2015

          http://www.elsevier.com/tdm/userlicense/1.0/

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