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      Naphthalimide-based light-induced nitric oxide-releasing nanoscale vesicles with visual detection and cytotoxicity studies

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          Summary

          The therapeutic potential of nitric oxide (NO) has been receiving increasing interest, but achieving controlled release under physiological conditions remains challenging. Herein, we report a colorimetric and fluorescence responsive naphthalimide-based amphiphilic N-nitroso-based NO donor (Nap-NO) and its NO-releasing behavior. Nap-NO was incorporated into phospholipid nanovesicles to make it biocompatible and water-soluble. Light-induced NO-releasing behavior and emission changes were monitored via UV-vis, colorimetric detection, IR (Infrared) spectroscopy studies, and Griess assay. The Nap-NO donor within the 1,2-dioleoyl- sn-glycero-3-phosphocholine (DOPC)-cholesterol vesicles exhibited a slower release rate, with a significantly extended half-life as compared to the only DOPC vesicles. Incorporating the Nap-NO into alginate hydrogel beads enables a simple, visual detection of NO release through color and emission changes. Bioimaging experiments within the HCT cell line reveal the use of the new NO donor for fluorescent bio-imaging and clearly illustrate their proficiency in killing cancer cells upon NO delivery in the presence of light.

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          Highlights

          • •

            Amphiphilic N-nitroso compound ( Nap-NO) for the light-controlled release of NO

          • •

            NO release from nanoscale liposomes modulated by lipid fluidity

          • •

            Nap-NO incorporated alginate polymer beads offers visual detection of NO release

          • •

            Liposomes co-embedded with Nap-NO exhibit cytotoxic effect to cancer cells

          Abstract

          Biological sciences; Cell; Materials science; Nanomaterials

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          Most cited references42

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          Nitric oxide release: part III. Measurement and reporting.

          Peter Coneski, Mark H. Schoenfisch (2012)
          Nitric oxide's expansive physiological and regulatory roles have driven the development of therapies for human disease that would benefit from exogenous NO administration. Already a number of therapies utilizing gaseous NO or NO donors capable of storing and delivering NO have been proposed and designed to exploit NO's influence on the cardiovascular system, cancer biology, the immune response, and wound healing. As described in Nitric oxide release: Part I. Macromolecular scaffolds and Part II. Therapeutic applications, the preparation of new NO-release strategies/formulations and the study of their therapeutic utility are increasing rapidly. However, comparison of such studies remains difficult due to the diversity of scaffolds, NO measurement strategies, and reporting methods employed across disciplines. This tutorial review highlights useful analytical techniques for the detection and measurement of NO. We also stress the importance of reporting NO delivery characteristics to allow appropriate comparison of NO between studies as a function of material and intended application.
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            Nitric Oxide Donors for Cardiovascular Implant Applications

            Noora Naghavi, Achala de Mel, Omid Sadeghi Alavijeh … (2013)
            In an era of increased cardiovascular disease burden in the ageing population, there is great demand for devices that come in to contact with the blood such as heart valves, stents, and bypass grafts that offer life saving treatments. Nitric oxide (NO) elution from healthy endothelial tissue that lines the vessels maintains haemostasis throughout the vasculature. Surgical devices that release NO are desirable treatment options and N-diazeniumdiolates and S-nitrosothiols are recognized as preferred donor molecules. There is a keen interest to investigate newer methods by which NO donors can be retained within biomaterials so that their release and kinetic profiles can be optimized. A range of polymeric scaffolds incorporating microparticles and nanomaterials are presenting solutions to current challenges, and have been investigated in a range of clinical applications. This review outlines the application of NO donors for cardiovascular therapy using biomaterials that release NO locally to prevent thrombosis and intimal hyperplasia (IH) and enhance endothelialization in the fabrication of next generation cardiovascular device technology.
            Article 0 comments Cited 47 times – based on 0 reviews     Review now
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              1,8-Naphthalimide-based fluorescent chemosensors: recent advances and perspectives

              Hong-Qiang Dong, Tai-Bao Wei, Xiao-Qiang Ma … (2020)
              Application of the classic fluorescent dye 1,8-naphthalimide. 1,8-Naphthalimide, as one of the classical dyes and fluorophores, has been widely used in analytical chemistry, materials chemistry, and biochemistry fields because of its excellent characteristic photostability, good structural flexibility, high fluorescence quantum yield, and large Stokes shift. This review mainly focuses on 1,8-naphthalimide and its derivatives in ion detection, molecular recognition, material applications, and bioimaging in the past five years. Simultaneously, we hope to develop more powerful fluorescent chemosensors for broad and exciting applications in the future.
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                Author and article information

                Contributors
                D. Amilan Jose
                Journal
                Journal ID (nlm-ta): iScience
                Journal ID (iso-abbrev): iScience
                Title: iScience
                Publisher: Elsevier
                ISSN (Electronic): 2589-0042
                Publication date PMC-release: 09 June 2024
                Publication date Collection: 19 July 2024
                Publication date (Electronic): 09 June 2024
                Volume: 27
                Issue: 7
                Electronic Location Identifier: 110230
                Affiliations
                [1 ]Department of Chemistry, National Institute of Technology Kurukshetra, Kurukshetra 136119, Haryana, India
                [2 ]Chemical Biology Unit, Institute of Nano Science and Technology (INST), Knowledge City, Sector 81, Mohali, Punjab 140306, India
                Author notes
                [∗ ]Corresponding author amilanjosenit@ 123456nitkkr.ac.in
                [3]

                Present address: Department of Chemistry, Malaviya National Institute of Technology, Jaipur, Rajasthan 302017, India

                [4]

                Lead contact

                Article
                Publisher Item ID: S2589-0042(24)01455-X Publisher ID: 110230
                DOI: 10.1016/j.isci.2024.110230
                PMC ID: 11259922
                PubMed ID: 39036042
                SO-VID: a39ffffb-a2d5-4f41-ae69-9d19f3c93126
                Copyright © © 2024 The Author(s)
                License:

                This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

                History
                Date received : 30 November 2023
                Date revision received : 2 March 2024
                Date accepted : 6 June 2024
                Categories
                Subject: Article

                Keywords: biological sciences,cell,materials science,nanomaterials
                Data availability:
                Keywords: biological sciences, cell, materials science, nanomaterials

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