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      Factores de riesgo asociados a la seroprevalencia de parvovirus canino en perros del municipio Boyeros, La Habana, Cuba Translated title: Risk factors associated to the seroprevalence of canine parvovirus in dogs from Boyeros municipality, Havana, Cuba

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          Abstract

          RESUMEN Con el objetivo de evaluar los factores de riesgo asociados a la seroprevalencia de parvovirus canino (PVC) en perros del municipio Boyeros, Cuba, se realizó un estudio observacional de tipo transversal. Para determinar los animales seropositivos a PVC se tomaron muestras de sangre a 160 canes y se evaluaron mediante un ELISA indirecto estandarizado por la división de Biotecnología y Control de la Calidad del CENPALAB. Como control positivo se empleó una mezcla de sueros previamente titulados de animales vacunados y, como control negativo, sueros de caninos libres de anticuerpos específicos. Se aplicó una encuesta a los propietarios de los canes y se identificaron los factores de riesgo asociados a la seroprevalencia de PVC mediante análisis de regresión logística binaria univariada y multivariada, utilizando el software estadístico SPSS versión 22.0. Se concluyó que la raza y el acceso a la calle resultaron factores de riesgo asociados a una alta seroprevalencia de parvovirus canino en los perros del municipio Boyeros, Cuba.

          Translated abstract

          ABSTRACT A cross-sectional observational study was carried out in order to evaluate the risk factors associated to the seroprevalence of canine Parvovirus (CPV) in dogs from Boyeros municipality, Cuba. To determine the CPV-seropositive animals, blood samples were taken from 160 dogs and evaluated by an indirect ELISA standardized by the Biotechnology and Quality Control division at CENPALAB (National Center for the Production of Laboratory Animals). A mixture of previously titrated sera from animals vaccinated against CPV was used as a positive control, and a canine serum free of specific antibodies as a negative control. A survey was applied to the owners of the dogs and the risk factors associated to the seroprevalence of CPV were identified by the univariate and multivariate binary logistic regression models, using the statistical software SPSS version 22.0. It was concluded that the breed and the street access resulted in risk factors associated to a high seroprevalence of canine Parvovirus in dogs from Boyeros municipality, Cuba.

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          The emergence of parvoviruses of carnivores

          The emergence of canine parvovirus (CPV) represents a well-documented example highlighting the emergence of a new virus through cross-species transmission. CPV emerged in the mid-1970s as a new pathogen of dogs and has since become endemic in the global dog population. Despite widespread vaccination, CPV has remained a widespread disease of dogs, and new genetic and antigenic variants have arisen and sometimes reached high frequency in certain geographic regions or throughout the world. Here we review our understanding of this emergence event and contrast it to what is known about the emergence of a disease in mink caused by mink enteritis virus (MEV). In addition, we summarize the evolution of CPV over the past 30 years in the global dog population, and describe the epidemiology of contemporary parvovirus infections of dogs and cats. CPV represents a valuable model for understanding disease emergence through cross-species transmission, while MEV provides an interesting comparison.
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            Long-term viremia and fecal shedding in pups after modified-live canine parvovirus vaccination

            Highlights • Dogs were administered type 2 or 2b modified-live canine parvovirus (CPV) vaccines. • Vaccine CPV-2b shedding occurred for a shorter period but with greater viral loads. • Viremia was detected for a longer period and at higher titers for CPV-2b than CPV-2. • CPV seroconvertion occurred earlier with CPV-2b than with CPV-2 vaccines. • Vaccine viruses were detected by PCR but not by antigen testing or hemagglutination.
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              Risk factors for death from canine parvoviral-related disease in Australia

              Canine parvovirus (CPV) is a highly contagious cause of serious and often fatal disease in dogs worldwide despite the availability of safe and efficacious vaccines. Although a number of studies have focussed on identifying risk factors in disease development, risk factors associated with death from CPV are largely unknown. In this study we analysed a total of 1451 CPV cases reported from an Australian surveillance system – using univariate and multivariate techniques – to determine significant risk factors associated with death and euthanasia. A crude case fatality rate of 42.3% was estimated – higher than has been reported previously. We found that 3.3% of CPV cases had a history of vaccination in the previous 12 months, despite having completed the primary puppy vaccination course. The majority (89.5%) of these cases occurred in dogs <12 months of age, indicating failure of the primary vaccination course to provide protective immunity (most likely due to interference of the vaccine antigen with maternal antibodies but other reasons are discussed). Extending the age at which the final puppy vaccination is administered might be one of several strategies to consider. The final multivariate model showed that in non-litter CPV cases, risk of death was significantly associated with season of diagnosis (summer) and pedigree type (hounds and non-sporting dogs). Euthanasia in non-litter CPV cases was significantly associated with season of diagnosis (summer), state of residence (Northern Territory/South Australia/Tasmania combined), age (
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                Author and article information

                Journal
                rsa
                Revista de Salud Animal
                Rev Salud Anim.
                Centro Nacional de Sanidad Agropecuaria (La Habana, , Cuba )
                0253-570X
                2224-4700
                August 2019
                : 41
                : 2
                : e10
                Affiliations
                [1] Mayabeque orgnameUniversidad Agraria de La Habana orgdiv1Facultad de Medicina Veterinaria orgdiv2Departamento de Clínica Cuba
                Article
                S0253-570X2019000200003 S0253-570X(19)04100200003
                a3440eff-e14d-41a7-b3ac-e19a6175f997

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 12 April 2019
                : 10 February 2019
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 28, Pages: 0
                Product

                SciELO Cuba

                Categories
                ARTÍCULOS ORIGINALES

                dogs,canine parvovirus,seroprevalence,risk factors,perros,parvovirus canino,seroprevalencia,factores de riesgo

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