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      “Something we must be proud of”: An interview and document study of team improvisation in the Dutch convalescent plasma project group

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          Abstract

          Background and Aims

          The COVID‐19 pandemic has revealed the importance of organizational resilience, the ability to effectively respond to a disruptive event before, during, and after it occurs. Team improvisation is an important component of organizational resilience as it describes characteristics of team skills and contextual qualities to create order from chaos. In Spring 2020, the Dutch national blood bank, began the convalescent plasma project (CCP). We aimed to study which elements of team improvisation in the CCP group were found and how lessons learned can contribute towards a non‐crisis situation for blood establishments.

          Methods

          Using Vera and Crossan's framework of improvisation, semi‐structured interviews with eight members of the CCP group were conducted. This was simultaneous to performing a document analysis of 21 Intranet posts and seven internal reports. MAXDA 2020 was used to conduct deductive and inductive thematic analyses.

          Results

          The CCP group showed strong characteristics of expertise and memory, teamwork quality, experimental culture, and real‐time information and communication that enabled them to improvise in all aspects of the donation process. Improvisation examples included comprehensive communication methods to identify and obtain new donors, asking additional intake questions and collecting additional aliquots to store while waiting for an internal antibody test to be developed, and regulatory respondents allowing a flexible change control procedure to meet the pace of the crisis. Training was evident to a lesser degree.

          Conclusion

          While improvisation impacted set routines and procedures, the safety and quality of the product were not affected. Regarding organizational resilience, our results showed that the CCP group “coped” well using elements of team improvisation. Blood establishments may consider introducing improvisational training and innovation teams throughout the organization for future preparedness and improving organizational resilience.

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          Most cited references36

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          Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

          In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS-CoV-2 antibodies, no overall clinical benefit was observed. Using a comprehensive translational approach, we unravel the virological and immunological responses following treatment to disentangle which COVID-19 patients may benefit and should be the focus of future studies. Convalescent plasma is safe, does not improve survival, has no effect on the disease course, nor does plasma enhance viral clearance in the respiratory tract, influence SARS-CoV-2 antibody development or serum proinflammatory cytokines levels. Here, we show that the vast majority of patients already had potent neutralizing SARS-CoV-2 antibodies at hospital admission and with comparable titers to carefully selected plasma donors. This resulted in the decision to terminate the trial prematurely. Treatment with convalescent plasma should be studied early in the disease course or at least preceding autologous humoral response development. There are currently no drugs available to treat SARS-CoV-2 infection. A promising alternative treatment for COVID-19 patients is convalescent plasma. Here, Gharbharan et al. collect covalescent plasma and report no overall clinical benefit for 86 patients hospitalized for COVID-19 and treated with 300 mL convalescent plasma.
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            Extreme events and disasters: a window of opportunity for change? Analysis of organizational, institutional and political changes, formal and informal responses after mega-disasters

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              Improvisation and Innovative Performance in Teams

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                Author and article information

                Contributors
                p.k.langisasongko@amsterdamumc.nl
                Journal
                Health Sci Rep
                Health Sci Rep
                10.1002/(ISSN)2398-8835
                HSR2
                Health Science Reports
                John Wiley and Sons Inc. (Hoboken )
                2398-8835
                14 July 2024
                July 2024
                : 7
                : 7 ( doiID: 10.1002/hsr2.v7.7 )
                : e2171
                Affiliations
                [ 1 ] Department of Public and Occupational Health Amsterdam UMC, Location VUmc Amsterdam the Netherlands
                [ 2 ] Department of Unit Transfusion Medicine Sanquin Blood Supply Foundation Amsterdam the Netherlands
                Author notes
                [*] [* ] Correspondence Praiseldy Langi Sasongko, Department of Public and Occupational Health, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.

                Email: p.k.langisasongko@ 123456amsterdamumc.nl

                Author information
                http://orcid.org/0000-0003-3614-1801
                Article
                HSR22171
                10.1002/hsr2.2171
                11247115
                39011149
                a336eb9d-bfed-4d70-84fc-5a4791f291d0
                © 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 22 May 2024
                : 04 February 2024
                : 27 May 2024
                Page count
                Figures: 0, Tables: 4, Pages: 14, Words: 10198
                Funding
                Funded by: Stichting Sanquin Bloedvoorziening , doi 10.13039/501100012023;
                Award ID: PPOC‐L2245
                Categories
                Original Research
                Original Research
                Custom metadata
                2.0
                July 2024
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.4.5 mode:remove_FC converted:15.07.2024

                convalescent plasma,healthcare management and organization,resilience,team improvisation,transfusion medicine (general)

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