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      Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

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          Abstract

          Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed.

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          Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.

          Min Zhao, Bing Song, Jin Pu … (2006)
          Wound healing is essential for maintaining the integrity of multicellular organisms. In every species studied, disruption of an epithelial layer instantaneously generates endogenous electric fields, which have been proposed to be important in wound healing. The identity of signalling pathways that guide both cell migration to electric cues and electric-field-induced wound healing have not been elucidated at a genetic level. Here we show that electric fields, of a strength equal to those detected endogenously, direct cell migration during wound healing as a prime directional cue. Manipulation of endogenous wound electric fields affects wound healing in vivo. Electric stimulation triggers activation of Src and inositol-phospholipid signalling, which polarizes in the direction of cell migration. Notably, genetic disruption of phosphatidylinositol-3-OH kinase-gamma (PI(3)Kgamma) decreases electric-field-induced signalling and abolishes directed movements of healing epithelium in response to electric signals. Deletion of the tumour suppressor phosphatase and tensin homolog (PTEN) enhances signalling and electrotactic responses. These data identify genes essential for electrical-signal-induced wound healing and show that PI(3)Kgamma and PTEN control electrotaxis.
          Article 0 comments Cited 286 times – based on 0 reviews     Review now
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            Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering.

            Laleh Ghasemi-Mobarakeh, P Prabhakaran, Hossein Baharvand … (2011)
            Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed. Copyright © 2011 John Wiley & Sons, Ltd.
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              Polymer structure-property requirements for stereolithographic 3D printing of soft tissue engineering scaffolds.

              Scott Verbridge, Christopher B. Williams, Akanksha Kanitkar … (2017)
              This review highlights the synthesis, properties, and advanced applications of synthetic and natural polymers 3D printed using stereolithography for soft tissue engineering applications. Soft tissue scaffolds are of great interest due to the number of musculoskeletal, cardiovascular, and connective tissue injuries and replacements humans face each year. Accurately replacing or repairing these tissues is challenging due to the variation in size, shape, and strength of different types of soft tissue. With advancing processing techniques such as stereolithography, control of scaffold resolution down to the μm scale is achievable along with the ability to customize each fabricated scaffold to match the targeted replacement tissue. Matching the advanced manufacturing technique to polymer properties as well as maintaining the proper chemical, biological, and mechanical properties for tissue replacement is extremely challenging. This review discusses the design of polymers with tailored structure, architecture, and functionality for stereolithography, while maintaining chemical, biological, and mechanical properties to mimic a broad range of soft tissue types.
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                Author and article information

                Contributors
                In-Seop Lee: inseop@yonsei.ac.kr
                Journal
                Journal ID (nlm-ta): Biomater Res
                Journal ID (iso-abbrev): Biomater Res
                Title: Biomaterials Research
                Publisher: BioMed Central (London )
                ISSN (Print): 1226-4601
                ISSN (Electronic): 2055-7124
                Publication date (Electronic): 5 December 2019
                Publication date PMC-release: 5 December 2019
                Publication date Collection: 2019
                Volume: 23
                Electronic Location Identifier: 25
                Affiliations
                [1 ]ISNI 0000 0001 0574 8737, GRID grid.413273.0, College of Life Sciences and Medicine, , Zhejiang Sci-Tech University, ; Hangzhou, 310018 People’s Republic of China
                [2 ]Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Hangzhou, 310018 People’s Republic of China
                [3 ]ISNI 0000 0004 1798 6507, GRID grid.417401.7, Department of Cardiology, , Zhejiang Provincial People’s Hospital, ; Hangzhou, 310014 People’s Republic of China
                [4 ]People’s Hospital of Hangzhou Medical College, Hangzhou, 310014 People’s Republic of China
                [5 ]ISNI 0000 0004 0470 5454, GRID grid.15444.30, Institute of Natural Sciences, , Yonsei University, ; 134 Shinchon-dong, Seodaemoon-gu, Seoul, 03722 Republic of Korea
                Article
                Publisher ID: 176
                DOI: 10.1186/s40824-019-0176-8
                PMC ID: 6896676
                PubMed ID: 31844552
                SO-VID: a2fe48a8-365c-4fea-a884-53ea238659e5
                Copyright © © The Author(s). 2019
                License:

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 5 August 2019
                Date accepted : 27 November 2019
                Categories
                Subject: Review
                Custom metadata
                issue-copyright-statement © The Author(s) 2019

                Keywords: electrical stimulation,tissue engineered materials,regenerative medicine
                Data availability:
                Keywords: electrical stimulation, tissue engineered materials, regenerative medicine

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