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      Dynamic Communication in Emergency Response: A Data-Driven Evaluation with the Emergency Communication Test

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          Abstract

          This research provides a data-driven assessment of dynamic communication in emergency response, highlighting important findings supported by actual data. In comparison to police officers in law enforcement situations, EMTs responded to medical crises 25% quicker, according to the response time research. When it came to communication accuracy, firemen performed at a 96% accuracy rate during fire situations, compared to a 91% accuracy rate in law enforcement circumstances. When compared to law enforcement situations, there was a 3% improvement in the completeness of information shared in fire incidents. Additionally, compared to accident situations, police officers' communication efficacy in law enforcement occurrences was 2.3% greater. These results highlight how crucial customized communication plans, data-driven insights, and technology and training integration are to maximizing dynamic communication in emergency response systems.

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          Pathogenesis of Preeclampsia and Therapeutic Approaches Targeting the Placenta

          Manoj Jena, Neeta Sharma, Matthew Petitt … (2020)
          Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of pregnancies worldwide and is characterized by hypertension and damage to multiple maternal organs, primarily the liver and kidneys. PE usually begins after 20 weeks’ gestation and, if left untreated, can lead to serious complications and lifelong disabilities—even death—in both the mother and the infant. As delivery is the only cure for the disease, treatment is primarily focused on the management of blood pressure and other clinical symptoms. The pathogenesis of PE is still not clear. Abnormal spiral artery remodeling, placental ischemia and a resulting increase in the circulating levels of vascular endothelial growth factor receptor-1 (VEGFR-1), also called soluble fms-like tyrosine kinase-1 (sFlt-1), are believed to be among the primary pathologies associated with PE. sFlt-1 is produced mainly in the placenta during pregnancy and acts as a decoy receptor, binding to free VEGF (VEGF-A) and placental growth factor (PlGF), resulting in the decreased bioavailability of each to target cells. Despite the pathogenic effects of increased sFlt-1 on the maternal vasculature, recent studies from our laboratory and others have strongly indicated that the increase in sFlt-1 in PE may fulfill critical protective functions in preeclamptic pregnancies. Thus, further studies on the roles of sFlt-1 in normal and preeclamptic pregnancies are warranted for the development of therapeutic strategies targeting VEGF signaling for the treatment of PE. Another impediment to the treatment of PE is the lack of suitable methods for delivery of cargo to placental cells, as PE is believed to be of placental origin and most available therapies for PE adversely impact both the mother and the fetus. The present review discusses the pathogenesis of PE, the complex role of sFlt-1 in maternal disease and fetal protection, and the recently developed placenta-targeted drug delivery system for the potential treatment of PE with candidate therapeutic agents.
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            Recently isolated antidiabetic hydrolysates and peptides from multiple food sources: a review

            Bababode Kehinde, Poorva Sharma (2020)
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              Revealing on hydrogen sulfide and nitric oxide signals co‐ordination for plant growth under stress conditions

              Simranjeet Singh, Vijay Kumar, Dhriti Kapoor … (2019)
              In the recent times, plants are facing certain types of environmental stresses, which give rise to formation of reactive oxygen species (ROS) such as hydroxyl radicals, hydrogen peroxides, superoxide anions and so on. These are required by the plants at low concentrations for signal transduction and at high concentrations, they repress plant root growth. Apart from the ROS activities, hydrogen sulfide (H2 S) and nitric oxide (NO) have major contributions in regulating growth and developmental processes in plants, as they also play key roles as signaling molecules and act as chief plant immune defense mechanisms against various biotic as well as abiotic stresses. H2 S and NO are the two pivotal gaseous messengers involved in growth, germination and improved tolerance in plants under stressed and non-stress conditions. H2 S and NO mediate cell signaling in plants as a response to several abiotic stresses like temperature, heavy metal exposure, water and salinity. They alter gene expression levels to induce the synthesis of antioxidant enzymes, osmolytes and also trigger their interactions with each other. However, research has been limited to only cross adaptations and signal transductions. Understanding the change and mechanism of H2 S and NO mediated cell signaling will broaden our knowledge on the various biochemical changes that occur in plant cells related to different stresses. A clear understanding of these molecules in various environmental stresses would help to confer biotechnological applications to protect plants against abiotic stresses and to improve crop productivity.
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                Author and article information

                Journal
                Title: BIO Web of Conferences
                Abbreviated Title: BIO Web Conf.
                Publisher: EDP Sciences
                ISSN (Electronic): 2117-4458
                Publication date Created: 2024
                Publication date (Electronic): January 12 2024
                Publication date (Print): 2024
                Volume: 86
                Page: 01099
                Article
                DOI: 10.1051/bioconf/20248601099
                SO-VID: a24e1a4a-6683-4089-8386-7710fad5e966
                Copyright © © 2024
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                https://creativecommons.org/licenses/by/4.0/

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