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      Clinical Observations of Kümmell Disease Treatment Through Percutaneous Fixation Combined with Vertebroplasty

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          Abstract

          Objective

          To explore the safety and efficacy of percutaneous pedicle screw fixation combined with vertebroplasty for the treatment of stage III Kümmell disease.

          Methods

          The clinical data and follow‐up results of 22 patients with Kümmell disease who were admitted to our department from 2014 to 2018 were analyzed. There were 14 females and eight males, and the Age range was 58–81 years. All patients were followed up for 24 months. The treatment method was percutaneous pedicle screw fixation combined with vertebroplasty. The patient general information such as age, gender, bedrest time and location of fracture vertebrae were recorded. The clinical symptoms and imaging data of visual analogue scale (VAS), bone cement leakage, Oswestry Disability Index (ODI), Cobb angle, anterior, middle and posterior height of the diseased vertebral body, and complications were recorded before operation and during follow‐up.

          Results

          For patients enrolled, no bone cement leakage was observed during the operation; no patients developed infections after operation. The operation was safe and resulted in a short bedrest time. The VAS score and ODI index at 3 and 24 months postoperative (2.86 ± 0.83, 31.68% ± 6.21%; 3.0 ± 0.82, 32.78% ± 6.05%) were significantly lower than that recoded preoperatively (7.59 ± 0.59, 71.5% ± 8.84%) ( P < 0.05). Additionally, there was no significant difference between the records at 3 and 24 months after operation ( P > 0.05). Imaging data showed that the bone cement and screws were in good position and did not move during postoperative and follow‐up. The anterior, middle and posterior height of the diseased vertebral body measured 2 days after surgery (23.46 ± 4.72, 23.12 ± 3.05, 25.81 ± 2.22) and at last follow‐up (20.83 ± 4.48, 21.78 ± 2.74, 24.74 ± 1.93) were higher than that recorded preoperatively (13.08 ± 4.49, 12.93 ± 3.53, 19.32 ± 2.73) ( P < 0.05), and the Cobb angle measured 2 days and 24 months after operation (9.57 ± 4.63, 10.68 ± 3.97) were lower than that recorded preoperatively (28.24 ± 8.95) ( P < 0.05), and no significant difference was found between the values recorded at 2 days and 24 months after operation ( P > 0.05). Follow‐up for 24 months, there was no re‐fracture of the diseased vertebrae and internal fixation loosening, but two cases of adjacent vertebral refracture complications occurred, and the effect was good after PVP treatment.

          Conclusion

          Short‐segment percutaneous pedicle screw fixation combined with vertebroplasty in the treatment of stage III Kümmel disease can effectively restore the height of the diseased vertebrae, kyphosis correction, reduce trauma, prevent the diseased vertebral body from collapsing again, and effectively improves clinical symptoms.

          Abstract

          Schematic diagram of percutaneous pedicle screw fixation combined with vertebroplasty for the treatment of stage III Kümmell disease. (A, D) Stage III Kümmell disease: vertebral compression, Cobb angle enlargement, posterior vertebral cortical rupture with spinal cord compression. (B, E) Percutaneous pedicle screw fixation: decrease the Cobb angle, enlarge the upper and lower gap of the diseased vertebrae and restore the height of the diseased vertebrae. (C, F) Percutaneous vertebroplasty: injection of bone cement to fill the enlarged diseased vertebral cavity to restore the height and stability of the vertebral body.

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          Most cited references43

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          Osteoporosis

          Fractures resulting from osteoporosis become increasingly common in women after age 55 years and men after age 65 years, resulting in substantial bone-associated morbidities, and increased mortality and health-care costs. Research advances have led to a more accurate assessment of fracture risk and have increased the range of therapeutic options available to prevent fractures. Fracture risk algorithms that combine clinical risk factors and bone mineral density are now widely used in clinical practice to target high-risk individuals for treatment. The discovery of key pathways regulating bone resorption and formation has identified new approaches to treatment with distinctive mechanisms of action. Osteoporosis is a chronic condition and long-term, sometimes lifelong, management is required. In individuals at high risk of fracture, the benefit versus risk profile is likely to be favourable for up to 10 years of treatment with bisphosphonates or denosumab. In people at a very high or imminent risk of fracture, therapy with teriparatide or abaloparatide should be considered; however, since treatment duration with these drugs is restricted to 18-24 months, treatment should be continued with an antiresorptive drug. Individuals at high risk of fractures do not receive adequate treatment and strategies to address this treatment gap-eg, widespread implementation of Fracture Liaison Services and improvement of adherence to therapy-are important challenges for the future.
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            Pedicle screw loosening: a clinically relevant complication?

            Literature studies showed a very wide range of pedicle screw loosening rates after thoracolumbar stabilization, ranging from less than 1 to 15 % in non-osteoporotic patients treated with rigid systems and even higher in osteoporotic subjects or patients treated with dynamic systems. Firstly, this paper aims to investigate how much this complication is affecting the success rate of pedicle screw fixation, in both non-osteoporotic and osteoporotic patients, and to discuss the biomechanical reasons which may be related to the variability of the rates found in the literature. The secondary aim was to summarize and discuss the published definitions and conventions about screw loosening from a clinical and radiological point of view.
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              Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty.

              The biomechanical behavior of a single lumbar vertebral body after various surgical treatments with acrylic vertebroplasty was parametrically studied using finite-element analysis. To provide a theoretical framework for understanding and optimizing the biomechanics of vertebroplasty. Specifically, to investigate the effects of volume and distribution of bone cement on stiffness recovery of the vertebral body. Vertebroplasty is a treatment that stabilizes a fractured vertebra by addition of bone cement. However, there is currently no information available on the optimal volume and distribution of the filler material in terms of stiffness recovery of the damaged vertebral body. An experimentally calibrated, anatomically accurate finite-element model of an elderly L1 vertebral body was developed. Damage was simulated in each element based on empirical measurements in response to a uniform compressive load. After virtual vertebroplasty (bone cement filling range of 1-7 cm3) on the damaged model, the resulting compressive stiffness of the vertebral body was computed for various spatial distributions of the filling material and different loading conditions. Vertebral stiffness recovery after vertebroplasty was strongly influenced by the volume fraction of the implanted cement. Only a small amount of bone cement (14% fill or 3.5 cm3) was necessary to restore stiffness of the damaged vertebral body to the predamaged value. Use of a 30% fill increased stiffness by more than 50% compared with the predamaged value. Whereas the unipedicular distributions exhibited a comparative stiffness to the bipedicular or posterolateral cases, it showed a medial-lateral bending motion ("toggle") toward the untreated side when a uniform compressive pressure load was applied. Only a small amount of bone cement ( approximately 15% volume fraction) is needed to restore stiffness to predamage levels, and greater filling can result in substantial increase in stiffness well beyond the intact level. Such overfilling also renders the system more sensitive to the placement of the cement because asymmetric distributions with large fills can promote single-sided load transfer and thus toggle. These results suggest that large fill volumes may not be the most biomechanically optimal configuration, and an improvement might be achieved by use of lower cement volume with symmetric placement.
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                Author and article information

                Contributors
                xzw6001@163.com
                Journal
                Orthop Surg
                Orthop Surg
                10.1111/(ISSN)1757-7861
                OS
                Orthopaedic Surgery
                John Wiley & Sons Australia, Ltd (Melbourne )
                1757-7853
                1757-7861
                02 June 2021
                July 2021
                : 13
                : 5 ( doiID: 10.1111/os.v13.5 )
                : 1505-1512
                Affiliations
                [ 1 ] First College of Clinical Medicine Shandong University of Traditional Chinese Medicine Jinan China
                [ 2 ] College of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Jinan China
                [ 3 ] Department of Orthopedics Affilited Hospital of Shandong University of Traditional Chinese Medicine Jinan China
                Author notes
                [*] [* ] Address for correspondence Zhan‐Wang Xu, MD, Department of Orthopaedics, Affilited Hospital of Shandong University of Traditional Chinese Medicine, 16369 Jingshi Road, Lixia District, Jinan, Shandong, China 250014. Tel: +86 0531 68617065; Fax: +86 0531 68616620; Email: xzw6001@ 123456163.com

                [†]

                Dong‐Hao Gan and Meng‐Ze Fang contributed equally to this work.

                Author information
                https://orcid.org/0000-0001-5741-3832
                Article
                OS12935
                10.1111/os.12935
                8313159
                34075704
                a2103070-0e24-4a1b-8dbd-ae1212c6a214
                © 2021 The Authors. Orthopaedic Surgery published by Chinese Orthopaedic Association and John Wiley & Sons Australia, Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 25 November 2020
                : 06 September 2020
                : 27 December 2020
                Page count
                Figures: 5, Tables: 2, Pages: 8, Words: 6223
                Funding
                Funded by: Natural Science Foundation of Shandong Province , doi 10.13039/501100007129;
                Award ID: ZR2020KH011
                Award ID: ZR2020MH362
                Funded by: Jinan Science and Technology Development Plan Project
                Award ID: 202019148
                Award ID: 201401261
                Funded by: National Natural Science Foundation of China , doi 10.13039/501100001809;
                Award ID: 81473709
                Funded by: National famous Traditional Chinese Medicine expert inheritance studio of Yixun Cao, (State Administration of Traditional Chinese Medicine 2018)
                Funded by: Shandong famous Traditional Chinese Medicine expert inheritance studio of Zhan‐Wang Xu, (Shandong Provincial Health Committee 2019).
                Categories
                Clinical Article
                Clinical Articles
                Custom metadata
                2.0
                July 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.4 mode:remove_FC converted:26.07.2021

                clinical outcome,kümmell disease,osteoporosis,percutaneous fixation,vertebroplasty

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