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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
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Abstract
The existence of a common lymphoid progenitor that can only give rise to T cells,
B cells, and natural killer (NK) cells remains controversial and constitutes an important
gap in the hematopoietic lineage maps. Here, we report that the Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo)
population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T,
B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation
potential either in vivo or in vitro. A single Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo)
cell could generate at least both T and B cells. These data provide direct evidence
for the existence of common lymphoid progenitors in sites of early hematopoiesis.