For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
31
views
366
references
 Top references
cited by
34
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      152
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Endocrine role of bone in the regulation of energy metabolism

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstracts

          Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ, suggesting that bone-derived factors regulate local bone metabolism and metabolic functions. In addition, these factors can regulate global energy homeostasis by altering insulin sensitivity, feeding behavior, and adipocyte commitment. These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis, treatment, and prevention of metabolic diseases such as osteoporosis, obesity, and diabetes mellitus. In this review, we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.

          Related collections

          Most cited references366

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Extracellular vesicles: Exosomes, microvesicles, and friends

          Graça Raposo, Willem Stoorvogel (2013)
          Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins, lipids, and RNA. Deficiencies in our knowledge of the molecular mechanisms for EV formation and lack of methods to interfere with the packaging of cargo or with vesicle release, however, still hamper identification of their physiological relevance in vivo. In this review, we focus on the characterization of EVs and on currently proposed mechanisms for their formation, targeting, and function.
          Article 0 comments Cited 1853 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Inflammation and metabolic disorders.

            Gökhan S. Hotamisligil (2006)
            Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.
            Article 0 comments Cited 1049 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.

              Toshimasa Yamauchi, Junji Kamon, Yusuke Ito … (2003)
              Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-alpha. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but to be structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR-alpha ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
              Article 0 comments Cited 615 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Xianghang Luo: xianghangluo@hotmail.com
                Journal
                Journal ID (nlm-ta): Bone Res
                Journal ID (iso-abbrev): Bone Res
                Title: Bone Research
                Publisher: Nature Publishing Group UK (London )
                ISSN (Print): 2095-4700
                ISSN (Electronic): 2095-6231
                Publication date (Electronic): 20 May 2021
                Publication date PMC-release: 20 May 2021
                Publication date Collection: 2021
                Volume: 9
                Electronic Location Identifier: 25
                Affiliations
                GRID grid.452223.0, ISNI 0000 0004 1757 7615, Department of Endocrinology, Endocrinology Research Center, , Xiangya Hospital of Central South University, ; Changsha, Hunan China
                Article
                Publisher ID: 142
                DOI: 10.1038/s41413-021-00142-4
                PMC ID: 8137703
                PubMed ID: 34016950
                SO-VID: a1ad5044-07f8-411e-8c90-25a79e09c122
                Copyright © © The Author(s) 2021
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 16 January 2020
                Date revision received : 20 December 2020
                Date accepted : 12 January 2021
                Categories
                Subject: Review Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2021

                Keywords: multihormonal system disorders,metabolic syndrome
                Data availability:
                Keywords: multihormonal system disorders, metabolic syndrome

                Comments

                Comment on this article

                scite_

                Similar content152

                See all similar

                Cited by33

                See all cited by

                Most referenced authors5,061

                See all reference authors