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      Applications of artificial neural networks in health care organizational decision-making: A scoping review

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          Abstract

          Health care organizations are leveraging machine-learning techniques, such as artificial neural networks (ANN), to improve delivery of care at a reduced cost. Applications of ANN to diagnosis are well-known; however, ANN are increasingly used to inform health care management decisions. We provide a seminal review of the applications of ANN to health care organizational decision-making. We screened 3,397 articles from six databases with coverage of Health Administration, Computer Science and Business Administration. We extracted study characteristics, aim, methodology and context (including level of analysis) from 80 articles meeting inclusion criteria. Articles were published from 1997–2018 and originated from 24 countries, with a plurality of papers (26 articles) published by authors from the United States. Types of ANN used included ANN (36 articles), feed-forward networks (25 articles), or hybrid models (23 articles); reported accuracy varied from 50% to 100%. The majority of ANN informed decision-making at the micro level (61 articles), between patients and health care providers. Fewer ANN were deployed for intra-organizational (meso- level, 29 articles) and system, policy or inter-organizational (macro- level, 10 articles) decision-making. Our review identifies key characteristics and drivers for market uptake of ANN for health care organizational decision-making to guide further adoption of this technique.

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          Most cited references75

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          The inevitable application of big data to health care.

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            Advantages and disadvantages of using artificial neural networks versus logistic regression for predicting medical outcomes.

            J V Tu (1996)
            Artificial neural networks are algorithms that can be used to perform nonlinear statistical modeling and provide a new alternative to logistic regression, the most commonly used method for developing predictive models for dichotomous outcomes in medicine. Neural networks offer a number of advantages, including requiring less formal statistical training, ability to implicitly detect complex nonlinear relationships between dependent and independent variables, ability to detect all possible interactions between predictor variables, and the availability of multiple training algorithms. Disadvantages include its "black box" nature, greater computational burden, proneness to overfitting, and the empirical nature of model development. An overview of the features of neural networks and logistic regression is presented, and the advantages and disadvantages of using this modeling technique are discussed.
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              Basic concepts of artificial neural network (ANN) modeling and its application in pharmaceutical research.

              Artificial neural networks (ANNs) are biologically inspired computer programs designed to simulate the way in which the human brain processes information. ANNs gather their knowledge by detecting the patterns and relationships in data and learn (or are trained) through experience, not from programming. An ANN is formed from hundreds of single units, artificial neurons or processing elements (PE), connected with coefficients (weights), which constitute the neural structure and are organised in layers. The power of neural computations comes from connecting neurons in a network. Each PE has weighted inputs, transfer function and one output. The behavior of a neural network is determined by the transfer functions of its neurons, by the learning rule, and by the architecture itself. The weights are the adjustable parameters and, in that sense, a neural network is a parameterized system. The weighed sum of the inputs constitutes the activation of the neuron. The activation signal is passed through transfer function to produce a single output of the neuron. Transfer function introduces non-linearity to the network. During training, the inter-unit connections are optimized until the error in predictions is minimized and the network reaches the specified level of accuracy. Once the network is trained and tested it can be given new input information to predict the output. Many types of neural networks have been designed already and new ones are invented every week but all can be described by the transfer functions of their neurons, by the learning rule, and by the connection formula. ANN represents a promising modeling technique, especially for data sets having non-linear relationships which are frequently encountered in pharmaceutical processes. In terms of model specification, artificial neural networks require no knowledge of the data source but, since they often contain many weights that must be estimated, they require large training sets. In addition, ANNs can combine and incorporate both literature-based and experimental data to solve problems. The various applications of ANNs can be summarised into classification or pattern recognition, prediction and modeling. Supervised 'associating networks can be applied in pharmaceutical fields as an alternative to conventional response surface methodology. Unsupervised feature-extracting networks represent an alternative to principal component analysis. Non-adaptive unsupervised networks are able to reconstruct their patterns when presented with noisy samples and can be used for image recognition. The potential applications of ANN methodology in the pharmaceutical sciences range from interpretation of analytical data, drug and dosage form design through biopharmacy to clinical pharmacy.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: Writing – original draftRole: Writing – review & editing
                Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – review & editing
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                19 February 2019
                2019
                : 14
                : 2
                : e0212356
                Affiliations
                [1 ] Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
                [2 ] Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, Toronto, Canada
                The University of Warwick, UNITED KINGDOM
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0002-8627-6483
                Article
                PONE-D-18-28913
                10.1371/journal.pone.0212356
                6380578
                30779785
                a196138c-8b71-49c9-8218-1869d3dc945b
                © 2019 Shahid et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 4 October 2018
                : 31 January 2019
                Page count
                Figures: 4, Tables: 2, Pages: 22
                Funding
                The authors received no specific funding for this work.
                Categories
                Research Article
                Computer and Information Sciences
                Artificial Intelligence
                Artificial Neural Networks
                Biology and Life Sciences
                Computational Biology
                Computational Neuroscience
                Artificial Neural Networks
                Biology and Life Sciences
                Neuroscience
                Computational Neuroscience
                Artificial Neural Networks
                Biology and Life Sciences
                Neuroscience
                Cognitive Science
                Cognitive Psychology
                Decision Making
                Biology and Life Sciences
                Psychology
                Cognitive Psychology
                Decision Making
                Social Sciences
                Psychology
                Cognitive Psychology
                Decision Making
                Biology and Life Sciences
                Neuroscience
                Cognitive Science
                Cognition
                Decision Making
                Computer and Information Sciences
                Neural Networks
                Biology and Life Sciences
                Neuroscience
                Neural Networks
                Computer and Information Sciences
                Artificial Intelligence
                Machine Learning
                Medicine and Health Sciences
                Health Care
                Health Care Providers
                Computer and Information Sciences
                Information Technology
                Data Mining
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Forecasting
                Physical Sciences
                Mathematics
                Statistics
                Statistical Methods
                Forecasting
                Computer and Information Sciences
                Neural Networks
                Feedforward Neural Networks
                Biology and Life Sciences
                Neuroscience
                Neural Networks
                Feedforward Neural Networks
                Custom metadata
                All relevant data are within the manuscript and its Supporting Information files.

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